ksp

Filanesib (ARRY 520) 是一种选择性的驱动蛋白纺锤体蛋白(KSP)的抑制剂(IC50 = 6 nM)，具有强大的抗增殖活性。

ARRY 520 hydrochloride 是一种驱动蛋白纺锤体蛋白 (KSP) 抑制剂。它通过凋亡诱导细胞死亡，并具有有效的抗增殖活性。

SB-743921 hydrochloride (SB743921 HCl) 是一种有效的驱动蛋白纺锤体蛋白 KSP 抑制剂，Ki 值为 0.1 nM。

PROTACKSP-IN-1 (Compound 21) 是一种 PROTAC 的纺锤体驱动蛋白 (KSP) 降解剂，能够在 HCT-116 细胞中以 DC50 为 114.8 nM 的浓度降解 KSP。该化合物抑制 HCT-116 细胞增殖的 IC50 为 10 nM，能够在 G2 M 期阻滞细胞周期，并诱导 HCT-116 细胞凋亡 (apoptosis)。同时，PROTACKSP-IN-1 在小鼠模型中展示了显著的抗肿瘤活性。

KSP ligand 1 是一种专门针对 KSP (Kinesin) 的蛋白质配体，常用于合成PROTAC KSP-IN-1，以便在癌症研究中应用。

KSP-IA is a potent, specific, allosteric, and cell-active KSP inhibitor.

Ispinesib (SB-715992) 是一种选择性可逆的驱动蛋白纺锤体蛋白抑制剂，具有抗肿瘤特性。

Larkspur alkaloid is a bioactive chemical.

KSPWFTTL is an immunodominant epitope derived from the p15E transmembrane protein. It is Kb-restricted and can enhance the susceptibility of a tumor cell line to cytotoxic T lymphocytes targeting anti-AKR/Gross MuLV.

Phenylethyl isothiocyanate (JC5411) 是一种 HDAC 抑制剂。它有可能用于治疗良性前列腺肥大。

MK-0731, a synthetic small molecule with potential antineoplastic activity, selectively inhibits kinesin spindle protein (KSP), leading to the inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase and apoptosis in

Photoclick sphingosine (Pacsph) 是一种具有光敏性和点击功能的鞘氨醇衍生物.在细胞中,此化合物能够整合进入内源性脂类代谢通道,并通过其可点击的炔烃基团实现可视化跟踪.Photoclick sphingosine 对于研究细胞内的鞘脂代谢过程及亚细胞定位至关重要.

Myristoylated Alanine-Rich C Kinase Substrate peptide (151-175) is a high affinity Protein Kinase C substrate.

S-Trityl-L-cysteine 是别构驱动蛋白Eg5的选择性抑制剂。rityl-L-cysteine 抑制基础 ATPase 活性的IC50为 1 μM，抑制微管激活的 ATPase 活性的IC50为 140 nM。S-Trityl-L-cysteine 显示出抗肿瘤活性。

(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM).

Filanesib (ARRY-520) targets the kinesin spindle protein (KSP) with potential antineoplastic activity. ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during

SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).

CW-069 是一种微管运动蛋白 HSET 的变构选择性抑制剂，IC50值为 75 μM，对 KSP 具有显着的特异性。

AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. KSP inhibitor AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly; activation of the spindle assembly checkpoint; induction of cell cycle arrest during the mitotic phase; and cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, this agent may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents. Eg5 is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis.

CK0106023 was specific inhibitor of KSP. In tumor-bearing mice, CK0106023 exhibited antitumor activity comparable to or exceeding that of paclitaxel and caused the formation of monopolar mitotic figures identical to those produced in cultured cells. KSP was most abundant in proliferating human tissues and was absent from cultured postmitotic neurons.

Mal-PEG8-Val-Ala-PAB-SB-743921 (Compound D7) 是一种用于 ADC 的药物-Linker偶联物。由KSP抑制剂SB-743921和连接子组成，此合成物可应用于ADC合成过程。

NHS-Ala-Ala-Asn-active metabolite 为一种可切割的抗体-药物偶联物 (ADC) 连接物，专用于合成激酶纺锤体蛋白 (KSP) 抑制剂。