ks i

KS I is a gonadotropin antagonist and is a cyclolignan isolated from extracts of Lycopus and Lithosperum after oxidation with caffeic acid.

Perfluorinated SAHA is an HDAC inhibitor for use in cancer treatment regimens, with demonstrated greater antiproliferative properties than SAHA . PFSAHA has also been shown to have higher selectivity for PA3774, an HDAC-like enzyme from P. aeruginosa, as well as other HDACs, which may prove beneficial for developing novel chemotherapeutic treatments for cancer.

KSI-3716 是一种 c-Myc 抑制剂，是一种膀胱内化疗剂，阻断 c-MYC MAX 与靶基因启动子形成复合物，通过诱导细胞周期停滞和细胞凋亡发挥作用，可用于膀胱癌的研究。

KSI-6666作为一种口服有效的竞争性鞘氨醇1-磷酸受体1 (S1PR1) 拮抗剂，其IC50值仅为6.4 nM。在自身免疫性脑脊髓炎模型及T细胞转移性结肠炎模型中，KSI-6666展示了显著的抗炎效果。

KS IV is a cyclolignan isolated from extract of Lycopus and Lithosperum after oxidation with caffeic acid.

PI5P4Ks-IN-2 是磷脂酰肌醇 5-磷酸 4-激酶 PI5P4Kγ 的抑制剂。PI5P4Ks-IN-2 靶向 PI5P4K 亚型，对 PI5P4Kα、PI5P4Kβ、PI5P4Kγ和PI5P4Kγ+具有抑制作用 ，IC50 值分别 <4.3、<4.6、6.2和0.32 。

DYRKs-IN-1 has antitumor activity. DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 9 nM and 5 nM for DYRK1B and DYRK1A, respectively.

DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.

TNKS-IN-41 highly potent and selective inhibitor of tankyrase.

Gentamicin (Centicin) 是一种广谱的氨基糖苷类抗生素，具有抗菌活性，抑制革兰氏阳性菌和革兰氏阴性细菌的生长，可用于研究眼部感染。

TNKS-IN-1 is a highly potent and selective inhibitor of tankyrase.

PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 μM, respectively). PKSI-527 reduces bradykinin generation induced by kaolin and λ-carrageenan ex vivo in human plasma. It also prolongs partial thromboplastin and euglobulin clot lysis times. In vivo, PKSI-527 (300 mg/kg per day) reduces hyperplasia, pannus formation, and infiltration of inflammatory cells in the tarsal joint of mice with collagen-induced arthritis.

PI5P4Ks-IN-1 (compound 7) 是一种与PI5P4Kγ结合的活性化合物。

LDHA PDKs-IN-2 (compound 20k) 是有效的 LDHA 和 PDKs 的双重抑制剂，IC50 值分别为 0.7 和 1.6 μM。LDHA PDKs-IN-2 会增加耗氧量并且减少乳酸的形成。LDHA PDKs-IN-2 显示了癌症研究的潜力，它可以减少 A549 细胞的增殖，EC50值为 15.7 μM。

LDHA PDKs-IN-1 (compound 20e) is a highly effective dual inhibitor of PDKs and LDHA, displaying IC50 values of 0.8 μM and 0.15 μM, respectively. It significantly suppresses A549 cell proliferation (EC50 = 13.2 μM), reduces lactate formation, and enhances oxygen consumption. This compound holds great promise for cancer research [1].

SIKs-IN-1（compound 8h）为一种嘧啶-5-羧酰胺衍生物，并充当盐诱导激酶（SIKs）的抑制剂。该化合物通过抑制SIK活性，上调IL-10抗炎细胞因子，下调IL-12促炎细胞因子，调控M1 M2巨噬细胞的极化，并在DSS诱导的结肠炎模型中展现出明显的抗炎效果。

PI5P4Ks-IN-3（化合物30）是一种PI5P4K共价抑制剂，针对PI5P4Kα的IC50为1.34 μM，对PI5P4Kβ的IC50为9.9 μM。然而，PI5P4Ks-IN-3在细胞内的活性较弱。

AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG 促进骨化作用。该化合物适用于研究成骨缺陷或骨矿物质密度（BMD）降低相关疾病，如骨质疏松症。

Pinobanksin是一种天然黄酮类化合物，在B细胞淋巴瘤细胞系和SH-SY5Y细胞中诱导凋亡。是一种强效抗氧化剂，能够抑制低密度脂蛋白（LDL）的过氧化，能够占据黄嘌呤氧化酶（XO）的催化中心从而进行抑制。Pinobanksin还表现出抗菌、抗炎、抗寄生虫、抗突变、抗增殖和抗血管生成的作用。

10-Hydroxydihydroperaksine是一种天然产物，属于夹竹桃科萝芙木属，其产品编号为 TN2568，CAS号为 451478-47-0。10-Hydroxydihydroperaksine可用作对照参考。

3,7-O-Diacetylpinobanksin是一种天然产物，属于松科松属，其产品编号为 TN2910，CAS号为 103553-98-6。3,7-O-Diacetylpinobanksin可用作对照参考。

Pinobanksin 3-acetate (3-O-Acetylpinobanksin) 是一种短叶松素酯衍生物,是一种强抗氧化剂，存在于向日葵和蜂蜜中，可以抑制低密度脂蛋白的过氧化.

Dihydroperaksine是一种天然产物，属于夹竹桃科萝芙木属，其产品编号为 TN3860，CAS号为 16100-84-8。Dihydroperaksine可用作对照参考。

Pinobanksin 3-O-propanoate is a natiral product from forest trees.