k. pneumonia

Kanamycin sulfate (Kanamycin monosulfate) 属于氨基糖苷类抗生素，通过与细菌 70S 核糖体亚基结合来干扰蛋白质合成。Kanamycin sulfate 具有抗菌活性，对革兰氏阳性菌和阴性菌及支原体都有抑制作用。

NSC 55655 (5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione) 具有抗菌和抗氧化活性，抑制 B. subtilis, S. aureus, K. pneumonia, E. coli, S. typhi ，A. niger 和 C. albicans 的增殖，可用于糖尿病。

KPC-2-IN-3 (Compound 3b) 是一种KPC-2抑制剂，其IC50为0.533 μM，Ki为0.194 μM。该化合物与Meropenem协同使用，对卡巴培南类耐药K.pneumoniaK47-25表现出抗菌活性，并能减少细菌数量，同时具有抗生素后效应。在小鼠肺炎模型中，KPC-2-IN-3显著降低了肺部细菌负荷。

MBL-IN-6 (Compound 6d) 是一种金属-β-内酰胺酶 (MBL) 抑制剂，对 NDM-1 和 VIM-2 的 Ki 分别为 2.6 μM 和 0.08 μM。MBL-IN-6 与 Imipenem 对产生 MBL 的临床分离株（如 E. coli SI-M001、K. pneumonia T2301 和 S. marcescens SI-1591）具有协同作用，其 MIC 为 2-64 μg/mL。不产生脱靶效应且无 ACE-1 抑制活性。MBL-IN-6 可用于抗菌素耐药性研究。

Hirsutide is a cyclotetrapeptide fungal metabolite produced by the entomopathogenic fungus Hirsutella. It has antibacterial activity against C. pyogenes, S. aureus, P. aeruginosa, and K. pneumonia (MICs = 25, 13, 6, and 21 μg/cm3, respectively). Hirsutide also has antifungal activity against C. albicans, M. audouinii, A. niger, and Ganoderma (MICs = 13, 6, 25, and 6 μg/cm3, respectively).

Antibacterial agent 111 (Compound 3) exhibits potent antibacterial activity against B. cereus and K. pneumonia, with MIC values of 3.90 μg/mL and 0.49 μg/mL, respectively. It achieves this antibacterial effect by strongly binding to specific residues of tyrosyl-tRNA synthetase [1].