ionizing

Psoralidin 是COX-2和5-LOX 的抑制剂，有抗癌，抗菌和抗炎作用。它显著下调NOTCH1信号传导，还极大地诱导活化氧产生。

Tirapazamine (Win59075) 是抗癌剂，对实体瘤中的缺氧细胞具有选择性细胞毒性，促使 DNA 中的单链和双链断裂，碱基损伤和细胞死亡。

AZ 14145845是一种高效且高度选择性的双Mer Axl激酶抑制剂，其pIC50值在pAxl和pMer中分别为7 nM和7.8 nM。在体内，AZ 14145845呈剂量依赖性地减少Mer和Axl激酶Ba F3肿瘤异种移植模型中的肿瘤生长。结合抗PD1抗体和电离辐射，AZ 14145845可提高源自MC38细胞的小鼠肿瘤存活率。此外，AZ 14145845可通过口服给药。

IRF1-IN-2 (Compound I-19) 是一种抑制IRF1的化合物。它减少了IRF1对CASP1启动子的结合并抑制细胞死亡信号通路，包括阻止Caspase 1、GSDMD、IL-1和PARP1的裂解，以及抑制TKB1的磷酸化，同时上调GPX4并下调FACL4。IRF1-IN-2 对由电离辐射引发的皮肤炎症性损伤具有保护作用。

IRF1-IN-1 (Compound I-2) 是一种IRF1抑制剂，可减少IRF1对CASP1启动子的募集，抑制细胞死亡信号通路（即抑制Caspase 1、GSDMD、IL-1和PARP1的裂解），并对电离辐射引起的皮肤炎症性损伤具有保护作用。

Motexafin gadolinium, also known as PCI 0120, is a synthetic metallotexaphyrin with radiosensitizing and chemosensitizing properties. Motexafin gadolinium accumulates in tumor cells preferentially due to their increased rates of metabolism, generating rea

Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes. Caldwell et al (2011) Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J.Med.Chem. 54 580 PMID:21186793

Valeryl-L-carnitine is a short-chain acylcarnitine and a derivative of L-carnitine . Valeryl-L-carnitine levels increase in the serum of rhesus monkeys following exposure to 7 and 10 Gray units (Gy) of ionizing radiation.[1]

XJB-5-131 is a synthetic, bi-functional antioxidant specifically designed to target mitochondria for the scavenging of reactive oxygen species (ROS) and electrons, thereby acting as a radical scavenger. Additionally, it serves as an effective protector and mitigator against ionizing irradiation for cord blood mononuclear cells (CB MNCs).

SU-11752 is a potent and selective DNA-PK inhibitor. Inhibition kinetics and a direct assay for ATP binding showed that SU11752 inhibited DNA-PK by competing with ATP. SU11752 inhibited DNA double-strand break repair in cells and gave rise to a five-fold sensitization to ionizing radiation. At concentrations of SU11752 that inhibited DNA repair, cell cycle progression was still normal and ATM kinase activity was not inhibited.

Etanidazole (SR-2508) is a 2-nitroimidazole drug with radiosensitizing properties. Etanidazole depletes glutathione and inhibits glutathione transferase, thereby enhancing the cytotoxicity of ionizing radiation. This agent may also be useful as an imaging agent for identifying hypoxic, drug-resistant regions of primary tumors or metastases. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

NU1085 is a potent poly(ADP-ribose) polymerase (PARP) inhibitors have been developed that potentiate the cytotoxicity of ionizing radiation and anticancer drugs. The biological effects of NU1085 [Ki = 6 nM], in combination with temozolomide (TM) or topotecan (TP) have been studied in 12 human tumor cell lines (lung, colon, ovary, and breast cancer). Cells were treated with increasing concentrations of TM or TP + - NU1085 (10 microM) for 72 h.

Reltecimod TFA（AB-103 TFA）是一种CD28(T淋巴细胞受体)模拟物，作为CD28的拮抗剂，能够抑制一系列细菌病原体对t细胞的刺激从而减轻急性炎症，用于治疗坏死性软组织感染（NSTI）。

2-Stearoyl-rac-glycerol, a monoacylglycerol with stearic acid at the sn-2 position, exhibits elevated levels in mouse plasma after low-dose ionizing radiation exposure and in rat kidney following ischemia-reperfusion injury models.

XRD-0394 是一种具有口服活性、强效且特异性的ATM和DNA-PKcs双重抑制剂，能在体外和体内治疗性电离辐射环境下显著增强肿瘤细胞杀伤作用，并在体外增强PARP和拓扑异构酶I抑制剂的效果。

Niacinamide ascorbate 是由烟酰胺（维生素 B3）和抗坏血酸（维生素 C）组成的维生素配合物。这种化合物能够减少经历电离辐射之后的健康风险，其中包括由放射线引发的急性白血病、乳腺癌、甲状腺癌以及其他体细胞和遗传突变的风险。