hydrogen sulfide-releasing

Desmethylanethol trithione (ADT-OH) 是合成硫化氢的供体。它利用上调 FADD 诱导细胞凋亡，并对体内黑色素瘤的形成具有一定的抑制作用，可用于研究癌症疾病。

FW1256 is a phenyl analog. It also a slow-releasing hydrogen sulfide (H2S) donor. FW1256 inhibits NF-κB activity and causes cell apoptosis. FW1256 shows potent anti-inflammatory effects. It also has the potential for cancer and cardiovascular disease trea

ATB-429 是一种具有释放 H2S 功能的美沙拉嗪衍生物，在肠易激综合征 (IBS) 模型中显示出显著的抗伤害和抗炎特性。通过释放硫化氢 (H2S)，该化合物能够调节健康和结肠炎后大鼠对结肠直肠扩张引发的超敏反应。ATB-429 减少了腹部戒断反应并抑制脊髓中 c-FosmRNA 的表达，可能有助于缓解胃肠道炎症相关的疼痛。此外，ATB-429 能下调结肠中环氧合酶-2 (COX-2) 和 IL-1β 的mRNA表达，而单一美沙拉嗪未表现出此效应。该作用机制与 ATP 敏感的 K+ (KATP) 通道有关，并可通过格列本脲逆转ATB-429 的作用证实。研究结果表明，ATB-429 在治疗与炎症相关的疼痛性肠道疾病时具备潜在的治疗优势。

AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP219 is a control compound for AP39, containing the triphenylphosphonium scaffold but lacking the H2S-releasing portion.

ATB-346, (S)-, is the S form of ATB-346. ATB-346 is a novel hydrogen sulfide-releasing anti-inflammatory drug which induces apoptosis of human melanoma cells and inhibits melanoma development in vivo.