hsp72

CCT251236 是基于细胞的表型高通量筛选 （HTS） 开发的化学探针，可用于筛选筛选来检测 HSF1 应激途径的抑制剂。CCT251236具有抗骨髓瘤活性，抑制 HSF1。

TRC051384 是一种热休克蛋白70 (HSP70) 诱导剂，可减少中风相关的神经元损伤并增加短暂性缺血性中风大鼠模型的存活率，激活热休克因子-1 并导致分子伴侣和抗炎活性升高，增强神经元和神经胶质细胞中 Hsp72 的表达。

KNK437 (Heat Shock Protein Inhibitor I) 是一种 HSP 抑制剂，抑制 HSP40，HSP70 和 HSP105 的活化。

TRC051384 HCl 是热休克蛋白 Hsp70 的诱导剂，可激活热休克因子-1 并增强神经元和神经胶质细胞中 Hsp72 的表达。

Heat shock protein (Hsp) inhibitor II is the active form of Hsp inhibitor I and a benzylidene lactam compound that prevents the synthesis of inducible Hsps, such as Hsp105, Hsp72, and Hsp40. Hsp inhibitor II decreases Hsp72 synthesis in vivo and reduces thermotolerance of tumors in SCC VII tumor-containing mice. At 100 μM, it inhibits the development of thermotolerance in COLO 320 DM cells. Inhibition of Hsp70 with Hsp inhibitor II in combination with amphotericin B increases susceptibility of AmB-susceptible (MICs = 0.058 versus 0.27 μg ml for combined and AmB alone, respectively) and AmB-resistant (MICs = 21.33 versus >32 μg ml for combined and AmB alone, respectively) strains of A. fumigatus.

Luminespib, also known as AUY-922, NVP-AUY922, VER52296, is a derivative of 4,5-diarylisoxazole and a third-generation heat shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. Hsp90 inhibitor AUY922 has been shown to bind with high affinity to and inhibit Hsp90, resulting in the proteasomal degradation of oncogenic client proteins; the inhibition of cell proliferation; and the elevation of heat shock protein 72 (Hsp72) in a wide range of human tumor cell lines.