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抑制剂&激动剂
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TargetMol产品目录中 "h-pgds"的结果
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TargetMol产品目录中 "

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  • 抑制剂&激动剂
    12
    TargetMol | Inhibitors_Agonists
  • 重组蛋白
    2
    TargetMol | Recombinant_Protein
  • PROTAC
    2
    TargetMol | PROTAC
  • 天然产物
    1
    TargetMol | Natural_Products
  • PROTAC(H-PGDS)-7
    T412672761281-50-7In house
    PROTAC(H-PGDS)-7 是一种有选择性的、有效的小分子造血前列腺素 D 合酶 (H-PGDS)PROTAC 降解剂,在 KU812细胞中展现出降解活性,DC50为 17.3 pM。PROTAC(H-PGDS)-7是一种类药化合物,能有效抑制前列腺素 D2 (PGD2)的产生,抑制炎症因子重生作用。PROTAC(H-PGDS)-7是治疗 DMD 和其他H-PGDS 相关疾病的候选化合物。
    • 待估
    35日内发货
    规格
    数量
  • HQL-79
    T15503162641-16-9
    HQL-79 is a selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor. It inhibits the synthesis of PGD2 and acts as an anti-allergic agent (Kd: 0.8 μM and IC50: 6 μM). It also shows no obvious effect on COX-1, COX-2, m-P
    • ¥ 945
    5日内发货
    规格
    数量
  • PROTAC(H-PGDS)-8
    T849242761281-51-8
    PROTAC(H-PGDS)-8,一种针对造血前列腺素D合酶 (H-PGDS) 的PROTAC降解剂,具有 0.14 μM 的IC50值。
    • 待询
    规格
    数量
  • HPGDS inhibitor 2
    GSK-2894631A
    T79482101626-26-8
    HPGDS inhibitor 2 (GSK-2894631A) 是高效的造血前列腺素 D 合成酶(H-PGDS)选择性抑制剂(IC50:9.9 nM)。
    • ¥ 535
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • HPGDS inhibitor 3
    T612502255311-93-2
    HPGDS inhibitor 3 is a powerful oral compound that selectively inhibits the hematopoietic prostaglandin D synthase (H-PGDS). With an IC50 value of 9.4 nM and EC50 of 42 nM, it demonstrates high potency in peripherally restricting H-PGDS. Moreover, HPGDS inhibitor 3 exhibits excellent selectivity with no associated central nervous system toxicity. This compound also possesses favorable pharmacokinetic properties in mouse, rat, and dog models. Additionally, HPGDS inhibitor 3 displays noteworthy anti-inflammatory activity [1].
    • ¥ 30570
    6-8周
    规格
    数量
  • F092
    T697302250261-59-5
    F092 是一种高效的造血前列腺素 D 合成酶 (H-PGDS) 抑制剂, 可以用于研究过敏性炎症和与血管相关的疾病。
    • ¥ 579
    In stock
    规格
    数量
  • hPGDS-IN-1
    T26811234708-04-3
    hPGDS-IN-1是 hPGDS 抑制剂,使用荧光偏振检测或通过 EIA 法测得的 IC50值为12 nM。
    • ¥ 745
    In stock
    规格
    数量
  • Sinensetin
    甜橙素, Pedalitin permethyl ether
    T4S02272306-27-6
    Sinensetin (Pedalitin permethyl ether) 是从水果中发现的一种甲基化黄酮,有很强的抗血管和抗炎症的能力。
    • ¥ 225
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • HPGDS inhibitor 1
    HPGDS-inhibitor-1
    T18041033836-12-2
    HPGDS inhibitor 1 是口服具有活性的HPGDS 选择性抑制剂,在酶和细胞分析中的IC50值分别为 0.6 nM 和 32 nM,但对 L-PGDS、mPGES、COX-1、COX-2 、5-LOX 无抑制作用。
    • ¥ 287
    In stock
    规格
    数量
  • TFC-007
    TFC007
    T24870927878-49-7
    TFC-007 是一种具有选择性和高效性的造血前列腺素 D 合成酶 (H-PGDS) 抑制剂,抑制炎症因子,可用于合成 H-PGDS 降解诱导剂 PROTAC (H-PGDS) -1 和研究雪松花粉诱导的豚鼠过敏性鼻炎。
    • ¥ 647
    In stock
    规格
    数量
  • tetranor-PGDM
    T3830670803-91-7
    Prostaglandin D2 is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. PGD2 is also produced in the brain by lipocalin-PGD-synthase also known as β-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. tetranor-PGDM is a major metabolite of PGD2 that is detectable in human and mouse urine. The levels of tetranor-PGDM and 2,3-dinor-11β-PGF2α , a related PGD2 metabolite, in human urine were found to be 1.5 ± 0.3 and 0.6 ± ng mg creatinine, respectively. tetranor-PGDM was detected in murine urine at a level of 8.1 ± 1.3 ng mg creatinine.
    • 待估
    35日内发货
    规格
    数量
  • TAS 205
    T383501584160-52-0
    TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50= 55.8 nM).1It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 μM, as well as over enzyme and receptor panels at 10 μM. TAS 205 inhibits production of prostaglandin D2induced by A23187 in KU812 human and RBL-2H3 rat basophils with IC50values of 78.3 and 181.3 nM, respectively. It inhibits ovalbumin-induced nasal lavage fluid eosinophil infiltration and late-phase nasal obstruction in an ovalbumin-sensitized guinea pig model of allergic rhinitis when administered at a dose of 30 mg kg. 1.Aoyagi, H., Kajiwara, D., Tsunekuni, K., et al.Potential synergistic effects of novel hematopoietic prostaglandin D synthase inhibitor TAS-205 and different types of anti-allergic medicine on nasal obstruction in a Guinea pig model of experimental allergic rhinitisEur. J. Pharmacol.875173030(2020)
    • 待估
    35日内发货
    规格
    数量
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