guanylate cyclase-in-1

Guanylate cyclase-IN-1 (Example 46) is a specific inhibitor of guanylate cyclase, employed in research related to cardiovascular diseases.

BI 703704 是一种有效的可溶性鸟苷酸环化酶(sGC)激活剂， 可抑制 ZSF1 大鼠的糖尿病肾病的进展。

MGV354 是一种可溶性鸟苷酸环化酶 (sGC) 激活剂，在 CHO 和 GTM-3E 细胞中 EC50值分别为 <0.5 nM 和 5 nM。

CFM 1571 hydrochloride is a chemical compound that acts as a stimulator of the nitric oxide receptor known as soluble guanylate cyclase (sGC). It demonstrates an EC50 value of 5.49 μM and an IC50 value of 2.84 μM. Soluble guanylate cyclase is an important signal-transduction enzyme that is activated by nitric oxide. The compound CFM 1571 hydrochloride shows potential for use in cardiovascular and other disease research [1] [2].

Guanylin (human) TFA is a 15-amino acid peptide that serves as an endogenous activator of intestinal guanylate cyclase. This compound is primarily located in the gastrointestinal tract, where it regulates electrolyte and water transport in the intestinal and renal epithelia through a mechanism dependent on cyclic GMP. [1][2]

Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B Kir6.2 over the SUR2A Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 = 4.4 µM). It decreases mean blood pressure, coronary resistance, and heart rate, as well as increases coronary sinus outflow, in dogs when administered intravenously at a dose of 1 mg kg. Nicorandil increases survival and decreases infarct size in a rabbit model of myocardial ischemia-reperfusion injury induced by left coronary artery occlusion. Formulations containing nicorandil have been used in the treatment of angina pectoris.

BAY-747 (BAY 1165747) 为一种通过口服生效且具有脑渗透性的sGC刺激剂。它能可逆地逆转L-NAME所诱导的记忆障碍并在大鼠中增强认知功能。BAY-747还可在有意识状态下降低正常血压及自发性高血压大鼠(SHR)的血压。此外，BAY-747在mdx mTRG2小鼠模型中改善了与Duchenne肌营养不良症(DMD)相关的骨骼肌功能。

亚甲蓝（Basic Blue 9）水合物，作为鸟苷酸环化酶（sGC）、单胺氧化酶A（MAO-A）及NO合酶（NOS）的抑制剂，常用于医疗作为血管加压剂及染料。该化合物通过影响一氧化氮合成酶 鸟苷酸环化酶信号通路，能够减少脉冲前抑制，同时作为一种氧化还原循环化合物，具有穿透血脑屏障的能力，并作为Tau蛋白聚集的抑制剂，有助于缓解脑水肿、减轻小胶质细胞活化和神经炎症。

Dolcanatide为一种对GC-C(鸟苷酸环化酶-C)具有口服活性的激动剂，展现出通便、抗痛及抗炎效果，适用于炎症性肠病研究。

Guanylin (mouse, rat) 是一种由15个氨基酸组成的多肽，并作为肠道鸟苷酸环化酶的激活剂。它可用于腹泻研究。

Prepro-Atrial Natriuretic Factor (26-55) (human) 为促进肾皮质与髓质循环GMP水平上升的多肽，同时也增强肾腺苷酸环化酶的活性。

C-Type Natriuretic Peptide (1-53), Porcine, Rat, mouse 主要作为颗粒鸟苷酸环化酶 B (pGC-B) 的激活剂，广泛存在于内皮细胞、肾脏和心脏中。该化合物在心脏和肾脏的成纤维细胞中通过产生二级信使cGMP发挥显著的抗纤维化功能。