fission

Liensinine 是一种自噬/线粒体自噬抑制剂。Liensinine 是从芙蕖种子胚中提取的，一种主要的异喹啉生物碱，具抗心律不齐、抗高血压、抗肺纤维化、血管平滑肌松弛等广泛的生物活性。

Solidagonic acid 通过促进异常单极纺锤体向双极纺锤体的转变来抑制 HSET 运动活动。Solidagonic acid 抑制裂殖酵母细胞死亡，并使有丝分裂纺锤体从单极形态逆转为双极形态。Solidagonic acid 对 Lactuca sativaL. 和 Lolium multiflorumLam 的幼苗具有生长抑制活性。

Heronamide C, a polyketide macrolactam antifungal agent synthesized by marine Actinomycetes, exhibits selective toxicity by inhibiting growth and promoting abnormal cell wall material accumulation in wild-type fission yeast cells (MIC = 0.13-0.28 μM), without affecting Gram-positive bacteria or human cancer cell lines, HeLa and MDA-MB-231. At 20 μM, it triggers reversible morphological alterations, notably the development of large intracellular structures, in HeLa cells.