ethacrynic acid

Ethacrynic acid (Edecrin) 是谷胱甘肽 S-转移酶抑制剂，也是NF-κB 信号传导途径的有效抑制剂，并且还调节白三烯的形成。它还可抑制 L 型电压依赖性和储存操作的钙通道，从而导致气道平滑肌细胞松弛。它是利尿剂，具有抗炎特性，可减轻类维生素 A 诱导的小鼠耳部水肿。

Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effects, notably reducing retinoid-induced ear edema in mice, and inhibits glutathione S-transferases (GSTs), making it a potent suppressor of the NF-kB signaling pathway. Additionally, ethacrynic acid modulates leukotriene formation. A variant, Ethacrynic acid D5, is distinguished by its deuterium labeling.

EA-B2L作为一种具有高效的谷胱甘肽S-转移酶 (glutathione S-transferase (GSTP)) 降解剂，显示出48 μM的DC50值。该化合物是Ethacrynic acid与Boc2Lys通过化学键结合形成的产物，在癌症研究领域中具有关键作用。

Ethacrynate Sodium, the sodium salt form of ethacrynic acid, could inhibit symport of chloride, potassium, and sodium primarily in the ascending limb of Henle, but also in the proximal and distal tubules.

CK1-IN-4 (Compound 59) 作为酪蛋白激酶CK1δ的抑制剂,其IC50值为2.74 μM.此化合物在经Ethacrynic acid处理的SH-SY5Y细胞中显示出了神经保护的特性.