docosahexaenoic acid

Docosahexaenoic Acid 属于天然产物，是一种 ω-3 脂肪酸，在脑和视网膜中较为丰富。Docosahexaenoic Acid 对大脑的生长和功能发育至关重要。

4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 μM, however it increased proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 μM.

17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).

Docosahexaenoic acid alkyne, an ω-alkyne derivative of docosahexaenoic acid, enables Cu(I)-catalyzed cycloaddition with azide-containing molecules for efficient click chemistry applications. It can be further utilized to produce alkyne-modified products like glycerophospholipids. Additionally, this compound permits the monitoring of fatty acid metabolism in cells through click chemistry linkage to fluorophores.

Docosahexaenoic Acid methyl ester (all cis-DHA methyl ester) 是甲基化的二十二碳六烯酸类似物，能够插入膜磷脂中而不被氧化或水解。

Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) 通过诱导小鼠纹状体脂质过氧化增强6-羟基多巴胺诱导的神经元损伤,可用于研究视网膜或神经元氧化疾病。

4-trans,7-cis,10-cis,13-cis,16-cis,19-cis-Docosahexaenoic acid 一种在生化反应中使用的试剂。

Docosahexaenoic acid-D5是Docosahexaenoic acid (T5369)的氘代物。Docosahexaenoic Acid (DHA)是一种在大脑和视网膜中大量存在的ω-3脂肪酸，主要来源于鱼油和母乳。

Docosahexaenoic acid-13C4是一种使用 13C 标记的 Docosahexaenoic acid。Docosahexaenoic Acid (DHA)是一种ω-3脂肪酸，广泛存在于大脑和视网膜中，可直接从鱼油和母乳中获取。

Docosahexaenoic Acid methyl ester (Standard) 是 Docosahexaenoic Acid methyl ester 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Docosahexaenoic Acid methyl ester (all cis-DHA methyl ester) 是甲基化的二十二碳六烯酸类似物，能够插入膜磷脂中而不被氧化或水解。

14(S)-HDHA (Standard) 是一种可用于分析的标准物质，通常用作 14(S)-HDHA 的研究和分析中参考的标准样品。Docosahexaenoic acid 是一种由营养物质衍生而来的ω-3 脂肪酸，它在大脑和视网膜中含量丰富，被认为在早期发育过程中以及在治疗炎症性疾病和癌症方面具有重要作用

Docosahexaenoic Acid-D5 (Standard) 是 Docosahexaenoic Acid-D5 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Docosahexaenoic acid-d5是Docosahexaenoic Acid的氘代物。Docosahexaenoic Acid (DHA)是一种在大脑和视网膜中大量存在的ω-3脂肪酸，主要来源于鱼油和母乳。

Cis-4,7,10,13,16,19-Docosahexaenoic Acid-[D5] Methyl Ester (Standard) 是 Cis-4,7,10,13,16,19-Docosahexaenoic Acid-[D5] Methyl Ester 的标准品，适用于定量分析、质量控制及生化实验等相关研究。

(±)4-HDHA (4-Hydroxy docosahexaenoic acid) 是一种 PPARγ 激动剂，具有抗炎活性，通过过氧化物酶体增殖物激活受体 γ（PPARγ） 直接抑制内皮细胞增殖和发芽血管生成，可用于研究糖尿病。

(±)14-HDHA是一种羟基二十二碳六烯酸，是DHA在细胞内通过酶促或非酶促反应生成的氧化代谢物，是15-PGDH的特异性底物之一并且可以被进一步氧化为具有抗炎性的14-oxoDHA，在原代肺泡巨噬细胞中，14-HDoHE 本身也能显著抑制 LPS 诱导的 IL-6 mRNA 表达，可能与哮喘等炎症性疾病有关。

LY3325656 is a GPR142 agonist suitable for clinical testing in human. LY3325656 demonstrated anti-diabetic benefits in pre-clinical studies and ADME/PK properties suitable for human dosing. LY3325656 is the first GPR142 agonist molecule advancing to phase 1 clinic trials for the treatment of Type 2 diabetes.

17(S)-HpDHA为主要由15-Lipoxygenase（LOX）同工酶：h15-LOX-1和h15-LOX-2与二十二碳六烯酸(DHA)反应生成。该化合物通过变构负向调控环氧化物合成，且能够抑制血小板聚集，其EC50值约为1μM。

1-Docosahexaenoyl-sn-glycero-3-phosphocholine, an ester product, is a phospholipid containing DHA (docosahexaenoic acid), often used in biomedical research as an important source of omega-3 fatty acids.

F 16915 can prevent heart failure-induced atrial fibrillation.F 16915 is a docosahexaenoic acid derivative.

(±)20-HDHA is an autoxidation product and is a racemic mixture of Docosahexaenoic acid (DHA).

1,3-Dilinoleoyl-2-docosahexaenoyl glycerol 是一种三酰甘油，其在 sn-1 和 sn-3 位连接Linoleic acid，在 sn-2 位连接Docosahexaenoic acid。

(±)10(11)-DiHDPA is produced from cytochrome P450 epoxygenase action on docosahexaenoic acid . It has been shown to inhibit VEGF-induced angiogenesis in mice and may have additional anti-inflammatory and anti-tumor effects.

Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 10,11-double bond of DHA. It has been detected in rat brain and spinal cord, as well as human serum, and acts as a substrate for soluble epoxide hydrolase with a Km value of 5.1 μM. (±)10(11)-EpDPA and other epoxy metabolites of DHA are reported to demonstrate antihyperalgesic activity in inflammatory and neuropathic pain models and to potently inhibit angiogenesis and tumor growth in in vitro assays.

(±)13(14)-DiHDPA is a metabolite of docosahexaenoic acid that is produced via oxidation by cytochrome P450 epoxygenases. Epoxygenase metabolites of DHA, including (±)13(14)-DiHDPA, are reported to inhibit angiogenesis, tumor growth, and metastasis.