deoxynivalenol

Deoxynivalenol (Vomitoxin) 是一种单端孢菌素家族镰刀菌属产生的霉菌毒素，常见于受到污染的食物和饲料中。Deoxynivalenol 通过紧密连接处的细胞旁路来穿过肠粘膜。Deoxynivalenol 转运不受P-糖蛋白 (PgP) 或多药耐药相关蛋白 (MRP) 抑制剂的影响。Deoxynivalenol 通常会导致人类和动物腹泻、呕吐和胃肠道炎症。

15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals and exhibits toxicity to HepG2 cells.

Deepoxy-deoxynivalenol is Metabolite of deoxynivalenol. Deepoxydeoxynivalenol is a macrocyclic polyol compound for proteomics research. Environmental contaminants; Food contaminants.

Deoxynivalenol-3-β-D-glucoside (DON-3-β-D-glucoside) 为脱氧雪腐镰刀菌烯醇的一种代谢产物，在实验条件下展示出相较于Deoxynivalenol的较低毒性。

Deoxynivalenol-BSA是Deoxynivalenol与牛血清白蛋白(BSA)缀合的半抗原-载体蛋白偶联物。Deoxynivalenol属于半抗原，单独存在时不能诱导免疫应答，需要偶联大分子蛋白质成为完全抗原才具有免疫原性。

3-Acetyldeoxynivalenol是一种发现于F. graminearum的真菌毒素，能够渗透血脑屏障，能够引起小鼠十二指肠和脾脏细胞坏死。

4-deoxy Nivalenol-13C15 is intended for use as an internal standard for the quantification of 4-deoxy nivalenol by GC- or LC-MS. 4-deoxy Nivalenol (T15097) is a trichothecene mycotoxin that has been found inFusarium.1It binds to eukaryotic ribosomes and inhibits protein synthesis in mice when administered at doses ranging from 5 to 25 mg/kg. 4-deoxy Nivalenol (T15097) (0.1 and 0.2 mg/kg)induces emesis in pigs and decreases feed consumption in pigs when administered at a dose of 40 ppb in the diet.2It induces lethality in mice (LD50= 46-78 mg/kg).34-deoxy Nivalenol has been found inF. graminearum-infected cereal grains such as wheat,barley,and corn.

3-Acetyldeoxy Nivalenol-13C17 is intended for use as an internal standard for the quantification of 3-acetyldeoxy nivalenol by GC- or LC-MS. 3-Acetyldeoxy nivalenol is a mycotoxin that has been found inF. graminearum.1

WML-01 是一种杀菌剂，对 F. graminearum、F. fujikuroi 和 S. sclerotiorum 的 EC50 分别为 0.079 μg/mL、0.72 μg/mL 和 2.02 μg/mL。它能够破坏 F. graminearum 的细胞膜并诱导脂滴沉积。另外，WML-01 抑制脱氧雪腐镰刀菌烯醇 (DON) 的生物合成，无交叉抗性，并有效阻止核糖体亚基组装，从而损害蛋白质合成能力。WML-01 在控制小麦赤霉病 (FHB) 的流行方面表现卓越。

13C15-Nivalenol is intended for use as an internal standard for the quantification of nivalenol by GC- or LC-MS. Nivalenol (T13797) is a trichothecene mycotoxin that has been found inFusarium.1It is lethal to mice (LD50= 6.9 mg/kg).2Nivalenol (5,10,and 15 mg/kg)also induces thymic,splenic,and Peyer's patch cell apoptosis in mice.3

Vomitoxin-BSA (DON-BSA) 是一种合成抗原，包含Deoxynivalenol (Vomitoxin) 和牛血清白蛋白(BSA)。Deoxynivalenol 是食物链中最重要的霉菌毒素之一。Vomitoxin-BSA 可用于制备抗Deoxynivalenol的单克隆抗体。