calcitonin

Endogenous calcitonin receptor agonist. Lowers systemic blood calcium levels and inhibits bone resorption.

Calcitonin (salmon) 是一种阿米林和卡西宁受体的双激动剂，是一种钙调节激素，能够刺激骨的生成并能抑制骨吸收。

Calcitonin-13CIC6,15NIC4(salmon) (Salmon calcitonin-13CIC6,15NIC4) TFA 是一种用13C和15N标记的Calcitonin(salmon)。该化合物作为一种钙调节激素具有双重功能，既作为胰岛淀粉样肽也是降钙素受体的激动剂，其主要功能在于促进骨骼形成及降低骨吸收的过程。

Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption. It belongs to the calcitonin family of peptides, which also includes amylin , calcitonin gene-related peptide , and adrenomedullin. The binding of salmon calcitonin to the human calcitonin receptor (CTR) is not modulated by receptor activity-modifying proteins (RAMPs), which influence affinity of human calcitonin to CTR. Salmon calcitonin binds to human CTR2 with IC50 values of 0.933, 0.224, 0.134, and 0.317 nM alone and with RAMP1, 2, or 3, respectively. It induces cAMP accumulation in COS-7 cells transfected with CTR2 (EC50 = 0.166 nM). Salmon calcitonin inhibits bone resorption by osteoclasts in a pit formation assay using rat bone slices (ID50 = 0.003 pg mL) and lowers calcium level in vivo in a bioassay of hypocalcemia in rats (ED15 = 33.9 mg kg). Formulations containing salmon calcitonin have been used to treat hypercalcemia, bone destruction by osteoporosis, and Paget's disease.

CalcitoninGene Related Peptide (CGRP) II, rat TFA，为CGRP受体激活剂，具有显著且持久的血管扩张效果，适用于心血管疾病研究。

[Tyr22]CalcitoninGene Related Peptide, (22-37), rat 是一种大鼠降钙素基因相关肽 (CGRP) 的 22-37 片段，靶向CGRP 受体和腺苷酸环化酶。降钙素 (calcitonin) 主要由甲状腺 C 细胞产生，而 CGRP 则分泌并储存在神经系统中。

Calcitonin,eel TFA is a thyroid hormone polypeptide that can regulate calcium homeostasis and is widely used in the study of postmenopausal osteoporosis.

Calcitonin, eel is a peptide hormone that plays a crucial role in maintaining calcium balance within the body. It is extensively utilized in the scientific investigation of postmenopausal osteoporosis, a condition characterized by decreased bone density and an increased risk of fractures in women after menopause.

Calcitonin Gene Related Peptide II is a potent, long-lasting vasodilator; activation of CGRP receptors on pancreatic β-cells increases plasma levels of pancreatic enzymes.

Calcitonin (8-32), salmon, is a highly selective amylin receptor antagonist. Calcitonin, a hormone involved in calcium and phosphorus metabolism, is primarily produced by the parafollicular or C cells in the thyroid gland of mammals.

Calcitonin, porcine 抑制1,25 (OH)2D3-刺激的猪破骨细胞分化。Calcitonin, porcine是一种多肽激素，通过减少肾脏对钙的重吸收和抑制破骨细胞的骨吸收来降低血清钙。Calcitonin, porcine可用于高钙血症的研究。

Calcitoninchicken 是一种激素，可调节钙代谢，抑制新生大鼠破骨细胞的细胞运动和骨吸收。

Calcitonin eel acetate (Calcitonin eel acetate (57014-02-5 Free base)) 是调节钙稳态的甲状腺激素肽。

Calcitonin(salmon)Acetate (47931-85-1(free base))(Salmon calcitonin) 是一种钙调节激素，用于治疗绝经后至少 5 年的女性骨质疏松症。

Rimegepant (BMS 927711) 是一种有效的降钙素基因相关肽 (CGRP) 受体拮抗剂 (Ki=0.027 nM，IC50=0.14 nM)。Rimegepant 可同时用于偏头痛急性发作治疗及预防性治疗。

Olcegepant (BIBN-4096) 是一种选择性的降钙素基因相关肽1 (CGRP1) 受体拮抗剂，IC50=0.03 nM，Ki=14.4 pM。

MK-3207 Hydrochloride (MK-3207 HCl) 是口服具有活力的CGRP receptor 拮抗剂，IC50=0.12 nM，Ki=0.024 nM。

CGRP (83-119), rat TFA (Calcitonin Gene Related Peptide(83-119), rat TFA) 是一种由 37 个氨基酸组成的神经肽降钙素家族，通过降钙素受体样受体起作用。

Vazegepant hydrochloride (Vazegepant HCl) 是一种用于偏头痛的鼻用 gepant，是一种高度亲和性CGRP 受体拮抗剂 (hCGRPKi=0.023 nM)。它可能有助于有效管理 COVID-19 相关肺部炎症。

Calcitonin Gene Related Peptide (CGRP) II, rat (TFA) is a neuropeptide with 37 amino acid.

Calcitonin Gene Related Peptide (CGRP) (83-119), rat is a 37 amino acid calcitonin family of neuropeptide, acts through calcitonin receptor-like receptor.

β-CGRP (mouse) 为一种降钙素基因相关肽，具有引发血管舒张的能力。该化合物适用于心血管、促炎反应、偏头痛及代谢方面的科研使用。

Atogepant (MK-8031) 是一种可口服且具有选择性和高效性的降钙素基因相关肽受体 (CGRP) 拮抗剂，可用于研究偏头痛。

CGRP (rat) acetateα-CGRP (rat) acetate（CGRP）。它是一种有效的血管扩张剂。