c14-hsl

N-tetradecanoyl-L-Homoserine lactone是一种长链的N-酰基高丝氨酸内酯 (AHL)和细菌群体感应信号分子，能够促进硅藻的生长，上调参与细胞内信号传导的基因。

Δ7(Z)-C14-HSL (Compound 12) 作为一种免疫抑制剂，具有抑制小鼠脾细胞增殖的IC50为17 μM的功能。此化合物被视为研究TNF-R驱动型免疫疾病（例如银屑病、类风湿性关节炎和1型糖尿病等自身免疫性疾病）的分子作用机制的有力工具。

N-3-oxo-tetradecanoyl-L-Homoserine lactone（3-oxo-C14-HSL）是一种小分子、可扩散的酰基高丝氨酸内酯信号分子，通过响应细胞密度协同调控 LuxIR 家族转录调节因子参与细菌群体感应。在生物膜形成过程中，该分子较短链 AHL 出现更晚，可刺激 putisolvin 生成并最终抑制生物膜形成。N-3-oxo-tetradecanoyl-L-Homoserine lactone 为研究细菌通讯、代谢及抗毒力策略提供了重要的分子工具。

Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group) and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family. C14:1-δ9-cis-(L)-HSL is a long-chain AHL that functions as a signaling molecule in the quorum sensing of A. vitis. Regulating bacterial quorum sensing signaling can be used to inhibit pathogenesis and thus, represents a new approach to antimicrobial therpy in the treatment of infectious diseases.