atg7

ATG7-IN-1 是一种选择性 ATG7 抑制剂，IC50 为 62 nM。

ATG7-IN-2 (compound 1) is a highly potent inhibitor of the ATG7 protein, displaying an IC 50 value of 0.089 μM. This compound effectively suppresses the activity of autophagy marker LC3B, thereby regulating the autophagy process [1].

ATG7-IN-3 (compound 18) is an effective inhibitor of ATG7, with a potency of 0.048 μM as determined by its IC50 value. It exhibits inhibitory actions on autophagy. Moreover, ATG7-IN-3 effectively hampers the development of endogenous LC3B puncta in the H4 neuroglioma cell line [1].

Antitumor agent-192 (Compound 2f) 是一种 β-咔啉抗肿瘤剂，通过ATG5 ATG7通路诱导HCT116细胞的自噬 (Autophagy)。其在多个人肿瘤细胞系中的IC50低于5 μM，并在同种移植小鼠结直肠癌模型中显著抑制肿瘤生长及减轻肿瘤重量。

Chromomycin A2 is an aureolic acid that has been found in several marine actinomycetes and has antibacterial and anticancer activities. Chromomycin A2 inhibits the growth of B. subtilis in an agar diffusion assay. It also inhibits the growth of human SGC7901 gastric cancer, HepG2 hepatocellular carcinoma, A549 lung epithelial adenocarcinoma, HCT116 colon cancer, and COC1 ovarian cancer cells, as well as human umbilical vein endothelial cells (HUVECs; IC50s = 4, 0.5, 3, 5, 5, and 8 nM, respectively). Chromomycin A2 (30 nM) halts the cell cycle in the G0 G1 phase and increases the protein levels of LC3A and LC3B in MALME-3M melanoma cells, indicating that it induces autophagy. It also increases the levels and promoter activity of the autophagic proteins ATG7 and ATG10 and reduces cell viability to 50% in human SCC-11 squamous cell carcinoma cells when used at a concentration of 30 nM.

Antitumor agent-82是一种有效的抗肿瘤剂。Antitumor agent-82 显示出抗增殖活性。Antitumor agent-82 通过 ATG5 ATG7信号通路诱导细胞自噬 (Autophagy)。

CPTH6, a thiazole derivative, selectively inhibits the lysine acetyltransferase activity of Gcn5 and pCAF without affecting p300 or CBP. It effectively blocks the acetylation of H3/H4 histones and α-tubulin in various leukemia cell lines, leading to reduced cell viability by arresting the cell cycle in the G0/G1 phase and inducing apoptosis. Additionally, CPTH6 disrupts autophagy across several tumor cell lines, primarily by interfering with ATG7-mediated autophagosomal membrane elongation.