at 527

Bemnifosbuvir hemisulfate (AT-527) 是一种 HCV 病毒复制抑制剂。

C527 是一种泛 DUB 酶抑制剂，对 USP1 UAF1 复合物具有高效力，IC50值为0.88 μM。

Selisistat R-enantiomer (EX-527 (R-enantiomer)) 是 Selisistat R 型对映体。Selisistat 是SIRT1的选择性抑制剂，IC50为98 nM。

CRX 527 是 TLR4 的配体，同时也是肽类癌症疫苗的佐剂，具备增强抗肿瘤免疫反应的潜力。CRX 527 还能诱导 HSC 分化，增加 LSK 细胞的比例和数量，促进其向巨噬细胞的分化，从而激活免疫防御，保护肠道上皮免受放射损伤。

Microginin 527, a compound found in Microcystis, is an inhibitor of protein phosphatase, ACE, and leucine aminopeptidase.

M 66,527 is a bioactive chemical.

PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 μM, respectively). PKSI-527 reduces bradykinin generation induced by kaolin and λ-carrageenan ex vivo in human plasma. It also prolongs partial thromboplastin and euglobulin clot lysis times. In vivo, PKSI-527 (300 mg/kg per day) reduces hyperplasia, pannus formation, and infiltration of inflammatory cells in the tarsal joint of mice with collagen-induced arthritis.

ALG.APV-527 (APV-527) 是一种双特异性抗体，作用于4-1BB (CD137) 和 5T4。ALG.APV-527 设计为只在与表达5T4的肿瘤细胞结合时，激活T细胞和自然杀伤(NK)细胞上的4-1BB。ALG.APV-527 展现出强效的抗肿瘤活性。

Gadoleic acid is a monounsaturated fatty acid.1,2It inhibits the dsDNA binding activity of p53 when used at a concentration of 1.2 nM.1Hepatic levels of gadoleic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet and increased in rats fed a high-cholesterol diet.2 1.Iijima, H., Kasai, N., Chiku, H., et al.The inhibitory action of long-chain fatty acids on the DNA binding activity of p53Lipids41(6)521-527(2006) 2.Serviddio, G., Bellanti, F., Villani, R., et al.Effects of dietary fatty acids and cholesterol excess on liver injury: A lipidomic approachRedox Biol.9296-305(2016)

AT-9010, a triphosphate derivative of AT-527, exhibits strong inhibitory activity against NiRAN, a crucial viral replication function. This compound effectively suppresses the replication of SARS-CoV-2.

AT-9010 tetrasodium is a triphosphate active metabolite derived from AT-527. It acts as a potent inhibitor of NiRAN, a crucial function for viral replication. Furthermore, AT-9010 tetrasodium demonstrates its ability to effectively inhibit the replication of SARS-CoV-2.

AT-9010 triethylamine, a triphosphate active metabolite of AT-527, is a potent inhibitor of the NiRAN enzyme, which is essential for viral replication. It effectively inhibits SARS-CoV-2 replication.