at 327

U 93385 is a 5-hydroxytryptamine (5-HT)1A receptor agonist that has bradycardic effects.

SL327 是能通过血脑屏障运输的选择性 MEK1 2 抑制剂，IC50 分别为 0.18 和 0.22 μM。

CELT-327是一种高效且选择性的荧光hA2B/A3腺苷受体拮抗剂，其Kivalues在A2B和A3受体上分别为35.6 nM和45.7 nM。在表达A2B腺苷受体的HCT116细胞中，CELT-327表现出剂量依赖性的膜荧光标记，荧光信号快速扩散并在细胞单层中均匀分布。在活的HCT116紧凑球体中，CELT-327展现出整个球体直径上的均匀染色，可达到球体深层区域。CELT-327可作为荧光腺苷受体探针用于荧光结合分析、活细胞成像、流式细胞术和荧光偏振分析。它是GPCR放射标记配体的合适替代品。激发和发射最大值（λ）分别为589 nm和616 nm。这些波长与作为TR-FRET分析中接受体染料使用兼容，与CoraFluor1 TR-FRET供体一同使用。

LRT 327 is a bioactive chemical.

ML327 是 MYC 的阻断剂，还可抑制 E-钙粘蛋白转录和逆转上皮间质转化。

F-327 is an oxytocin antagonist.

MB327是一种具有双吡啶结构的非肟类化合物，具备恢复神经肌肉功能的能力。该化合物通过典型的II型PAM机制，恢复卡巴胆碱脱敏后的烟酰胺乙酰胆碱受体(nAChRs)活性。此外，MB327还能有效中和神经毒剂的中毒效果。

HIVgp120 (318-327) 是源自 HIV-1 IIIB 株系包膜蛋白的短肽序列 (rgpgrafvti)，对应于糖蛋白稳定的 C 端区域。该片段是 HIV 疫苗 V3 肽表位的一部分，亦称为 I10 肽。尽管 HIVgp120 (318-327) 缺少使表位特异性 CTL 识别的 A2 锚定残基，它仍具备促成混杂 A2 结合的结构特性。

Pal-KTTKS is a lipidated pentapeptide consisting of a fragment of the type I collagen C-terminal propeptide conjugated to palmitic acid .1 It increases collagen production in human corneal and dermal fibroblasts when used at concentrations of 0.002, 0.004, and 0.008 wt%.2 Following topical administration, pal-KTTKS (50 μg/cm2) is found in the stratum corneum, epidermis, and dermis of isolated hairless mouse skin.1 It can self-assemble into flat tapes and extended fibrillar structures.3 Pal-KTTKS has been detected in anti-wrinkle creams.4 |1. Choi, Y.L., Park, E.J., Kim, E., et al. Dermal stability and in vitro skin permeation of collagen pentapeptides (KTTKS and palmitoyl-KTTKS). Biomol. Ther. (Seoul) 22(4), 321-327 (2014).|2. Jones, R.R., Castelletto, V., Connon, C.J., et al. Collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts. Mol. Pharm. 10(3), 1063-1069 (2013).|3. Castelletto, V., Hamley, I.W., Whitehouse, C., et al. Self-assembly of palmitoyl lipopeptides used in skin care products. Langmuir 29(29), 9149-9155 (2013).|4. Chirita, R.-I., Chaimbbault, P., Archambault, J.-C., et al. Development of a LC-MS/MS method to monitor palmitoyl peptides content in anti-wrinkle cosmetics. Anal. Chim. Acta 641(1-2), 95-100 (2009).