asic3

5-(N,N-Hexamethylene)-amiloride (5-HMA) 是 amiloride 的衍生物，也是 Na+ H+交换抑制剂，可降低白血病细胞的细胞内 pH (pHi) 并诱导凋亡。

Neuropeptide SF(mouse,rat) acetate (Neuropeptide SF(mouse,rat) acetate (230960-31-3 free base)) 是一种有效的神经肽 FF 受体激动剂，对 NPFF1 和 NPFF2 的 Ki 分别为 48.4 nM 和 12.1 nM。它增加了异源表达的酸感应离子通道 3 (ASIC3) 的持续电流的幅度。

A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM, and it has antidepressant and antinociception effects[1][2].

Neuropeptide SF (human) 显着增加异源表达 ASIC3 的持续电流幅度（FMRFamide 和 NPFF 分别为 12 倍和 19 倍和 9 倍），EC50 约为 50 μM。

ASIC blocker (IC50 values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.

3-(3,6-dichloro-9H-carbazol-9-yl)propanoic acid （DCPPA）是一种ASIC3抑制剂，可以有效阻断ASIC3介导的疼痛和炎症，已被证明在治疗中风、癫痫和癌症等其他疾病方面具有潜在应用。

Neuropeptide SF (mouse,rat) TFA 作为一种高效的 neuropeptide FF receptor 激动剂，对 NPFF1 和 NPFF2 的Ki值分别达到 48.4 nM 和 12.1 nM。该化合物还能够提升异表达的酸感离子通道 3 (ASIC3) 的持续电流幅值。

APETx2 TFA 是可来自Anthopleura elegantissima 的海葵肽，是选择性的、可逆的酸敏感的离子通道ASIC3 (acid-sensing ion channel)抑制剂，其 IC50值为 63 nM. APETx2 作用在ASIC3 通道外部。APETx2 TFA 能够逆转酸性诱导的炎症疼痛。

Mambalgin 1 TFA, a selective inhibitor of ASIC1a (with IC50 values of 192 nM for human ASIC1a and 72 nM for the ASIC1a 1b dimer), preferentially binds to the channel in its closed inactive state. It demonstrates selectivity for ASIC1a over a range of other channels, including ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2, and Kv1.2. In vivo, Mambalgin 1 TFA effectively prolongs the latency of the withdrawal response in mouse tail-flick and paw-flick tests.

6-Iodoamiloride作为一种有效的酸敏感离子通道1(ASIC1)抑制剂，其IC50值为88 nM。同时，该化合物能够抑制大鼠背根神经节神经元中ASIC3介导的电流，其IC50值为230 nM。

GMQ hydrochloride (NSC-403387 hydrochloride) 是一种有效的选择性酸感应离子通道 (ASIC) 调节剂。它在中性 pH 值下激活 ASIC3 通道并阻止酸引起的最大峰值电流。

Selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Binds to closed/inactive channel. Selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Increases late

Acid-sensing ion channel 3 (ASIC3) channel blocker (IC50 values are 63 and 175 nM for homomeric rat and human ASIC3 channels). Also inhibits NaV1.8 and NaV1.2 channels (IC50 values are 55 and 114 nM respectively). Demonstrates analgesic properties against