as-101

Ossirene (AS101) 是一种免疫调节抑制剂，是一种新型 IL-1beta 转化酶抑制剂，可用于自身免疫性疾病和某些恶性肿瘤。它通过抑制IL-10消除 STAT3 的磷酸化，有效抑制Caspase-1。

LAS101057 是一种新型可口服且具有有效性和选择性的 A2B receptor 拮抗剂，可用于研究哮喘。

Diphenylmethane是一个片段分子，CAS号为101-81-5，可作为分子拼接、扩展和修饰的重要骨架，为新型候选药物的设计与筛选提供结构基础与研究工具，常用于药物发现、药物合成等相关研究。

Nortriptyline hydrochloride (ELF-101 hydrochloride) 是一种三环类抗抑郁药，用于缓解抑郁症的症状。它是 Amitriptyline 的主要活性代谢产物，是有效自噬抑制剂。

VH 101, phenol是基于 VH032 的 VHL 配体。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子，如 PROTAC 1。PROTAC 1 是 SMARCA2 和 SMARCA4 的部分降解剂。

SMARCA2-IN-2 (Compound I-25) 作为SMARCA2抑制剂，具有IC50值在101-500 μM范围内，主要应用于癌症相关的研究领域。

Prodipine (又名BY-101) 属于二苯基哌啶衍生物，用作抗帕金森病化合物。

STAT3-IN-37 (Compound 101) 是STAT3的抑制剂，IC50值在 15 nM（通过DNA-HTRF 分析）或 2 nM（基于人全血 SOCS3 qPCR 分析）。

PAD4-IN-5 (Example 18) 是一种PAD4抑制剂，在 50 µMCa2+和 1 mMCa2+条件下，对人类PAD4 (hPAD4) 的IC50分别为 ≤10 nM和101-500 nM。PAD4-IN-5 可用于类风湿性关节炎 (RA) 等自身免疫性疾病的研究。

AR antagonist 14 是一种用于 PROTAC 靶蛋白的配体 (Ligands for Target Protein for PROTAC)，可与 VH 101-amide-piperidine-Pip-alkyne 结合，用于合成 PROTAC 降解剂 (ARD-69)。

Zelecimentbasivarsen (DYNE-101) 是一种抗体寡核苷酸偶联物 (AOC)，由与肌肉细胞转铁蛋白受体1 (TfR1) 结合的Fab抗体Zeleciment与反义寡核苷酸Basivarsen组成。其通过靶向变异的I型肌营养不良蛋白激酶 (DMPK) RNA 进行RHase H介导的降解，应用于肌营养不良症1型 (DM1) 的研究。

Rivoglitazone, also known as CI-1037; CS-011; DE-101; R-119702; Rivo, is a peroxisome proliferator-activated receptor γ agonist (PARPγ agonist) potentially for the treatment of type 2 diabetes. Rivoglitazone has been shown, through small clinical studies,

Viquidacin ( NXL-101) is an oral/intravenous antibiotic that targets Gram-positive bacteria such as MRSA. In 2008, Novexel announced it had discontinued the development of Viquidacin (NXL 101).

11-cis Retinol是一种维生素A的异构体，是红杆视蛋白的激动剂和红锥视蛋白的反向激动剂。

OY-101为口服生效的特异性P-glycoprotein(P-gp)抑制剂。该化合物可增强耐药性肿瘤的敏感性，并有效逆转多药耐药现象。相较于Tetrandrine，OY-101在水溶性、细胞毒性以及逆转活性方面均表现出改进。

Ceftolozane, also known as FR-264,205 and CXA-101; is an antibiotic drug from the cephalosporin family, approved for the treatment of infections with gram-negative bacteria, or gram-positive bacteria. Ceftolozane is of great benefit due to its ability to target bacteria that have become resistant to conventional antibiotics. Ceftolozane is combined with the β-lactamase inhibitor tazobactam, as multi-drug resistant bacterial infections will generally show resistance to all β-lactam antibiotics unless this enzyme is inhibited. .

EVT-101, also known as ENS-101, is an experimental medication which originated from Roche and is under development by Evotec AG for the treatment of major depressive disorder. It acts as a selective NMDA receptor subunit 2B (NR2B) antagonist.

INU-101 is an 11β-HSD1 inhibitor. In KKAy mice, ob/ob mice, and ZDF rats, oral administration of INU-101 led to enhanced insulin sensitivity and the lowering of the fasting level of glucose in the blood. INU-101 therefore shows promise as a potential treatment for type 2 diabetes and metabolic syndrome.

KR-67607, also known as NTX-101 is novel selective 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor. KR-67607 decreased 4-hydroxynonenal expression and increased antioxidant and mucus secretion in BAC-treated rat eyes. KR-67607 showed its protective effects against ischemia-reperfusion-induced eye injury. KR-67607 effectively reduced cortisol levels in mouse eyes and maintained the trabecular meshwork (TM) structure in the presence of transient ischemic stress. Furthermore, KR-67607 reversed the elevation of intra-ocular pressure (IOP), suggesting that the TM structure maintained by KR-67607 prevented the excessive rise in IOP that exacerbates glaucoma.

Vidofludimus (4sc-101 ; SC12267) hemicalcium 是一种口服有效的二氢乳清酸脱氢酶 (DHODH) 的抑制剂，也是法尼醇 X 受体 (FXR) 调节剂。Vidofludimus hemicalcium 作为一种免疫调节剂，可用于研究自身免疫性疾病，如炎症性肠病 (IBD)。Vidofludimus hemicalcium 还可通过靶向FXR 用于脂肪肝的研究。

VMY-1-101 is a synthesized fluorescent CDK inhibitor. VMY-1-101 demonstrates potent CDK inhibitory activity, enhanced induction of G2/M arrest and modest apoptosis as compared to purvalanol B.

EVT-101 is a GluN2B antagonist, binding at the same GluN1/GluN2B dimer interface as ifenprodil but adopting a remarkably different binding mode involving a distinct subcavity and receptor interactions.

Foslevcromakalim(QLS-101)是一种三磷酸腺苷敏感钾通道(K ATP)开放剂，能够在体内被碱性磷酸酶转化为活性形式，能够降低正常血压的小鼠的眼压，可用于研究青光眼。

HCVCore Protein (107-114) 是主要线性 HCV 核心区域中免疫原性极低的残基。HCVCore Protein (107-114) 被鉴定为 101-118 区域内的结合位点，其包含基因型 Ⅰ/Ⅱ 和基因型 Ⅲ/Ⅵ 之间不同的两个残基。HCVCore Protein (107-114) 可能是传播 HCV 血清型的潜在位点。