apc/c

TASIN-1 Hydrochloride (TASIN-1 HCl) 是一种截短型 APC 的选择性抑制剂，通过降低细胞胆固醇水平和通过结肠癌细胞中的 ER 应激 ROS JNK 信号传导诱导凋亡细胞死亡来选择性杀死表达截短型 APC 的结肠直肠癌细胞。

TAME hydrochloride (Tos-Arg-OMe HCl) 是后期促进复合体(APC C 或 APC)的抑制剂，可与 APC C 结合并阻止其通过 Cdc20 和 Cdh1 活化，产生有丝分裂阻滞。它是一种 od 氨基酸衍生物。

Activated Protein C (390-404), human acetate (Activated Protein C ) 抑制 APC 抗凝活性。

CFM 4 是一种有效的小分子 CARP-1 APC-2 拮抗剂，阻止 CARP-1 与 APC-2 结合，促使 G2M 细胞周期阻滞，引起细胞凋亡，其 IC50 范围为 10-15 μM。CFM 4 对耐药人类乳腺癌细胞的生长有抑制作用。

TAME (Tosyl-Arginine Methyl Este) 是后期促进复合体 (APC C 或 APC) 的抑制剂， 通过与 APC 激活剂细胞分裂周期 20 （Cdc20） 的 C 末端异亮氨酸-精氨酸尾部竞争 APC 结合来抑制 APC 依赖性蛋白水解。TAME 与 APC 结合并阻止其被 Cdc20 和 Cdh1 激活.

Apcin 是后期促进复合物 环体 (APC C(Cdc20)) E3 连接酶活性的有效竞争性抑制剂，可通过与 Cdc20 结合并阻止底物识别竞争性地抑制 APC C 依赖性泛素化。它占据 WD40 结构域侧面的 D-box 结合口袋，并可以延长有丝分裂。它通过阻断有丝分裂退出并通过共同添加 Ts-Arg-OMe 协同放大而起作用。

TASIN-1 是截短的APC 基因（结肠腺瘤样息肉基因）选择性抑制剂，可以抑制胆固醇生物合成并发挥细胞毒性作用。它是一种预防和干预APC 突变型结直肠癌的潜在治疗策略。

Apcin A HCL 是 Apcin 衍生物。 它是一种后期促进复合物 (APC) 抑制剂。它与 Cdc20 强烈相互作用，并抑制 Cdc20 底物的泛素化。它可用于合成 PROTAC CP5V。

TASIN-30，作为EBP的抑制剂，展现出对EBP的竞争性抑制，其EC50值为0.097 μM；而对DHCR7的竞争性抑制EC50值则为50 μM。

Unesbulin (PTC596) 是一种口服有效和选择性的 B 细胞特异性莫洛尼氏鼠白血病病毒整合位点 1 抑制剂。它在急性髓细胞白血病细胞中可下调 MCL-1 并诱导不依赖 p53 的线粒体凋亡，具有抗白血病作用。

MHAPC-Chol is a cationic cholesterol. MHAPC-Chol, as part of a lipoplex with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells in a luciferase assay without affecting cell viability. It has also been used to deliver siRNA into mice via intravenous injection, resulting in MHAPC-chol accumulation in the liver.

HAPC-Chol is a cationic cholesterol. HAPC-Chol, as part of a lipoplex with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells in a luciferase assay without affecting cell viability. It has also been used to deliver siRNA into mice via intravenous injection, resulting in HAPC-chol accumulation in the lungs.

DMHAPC-Chol is a cationic cholesterol. Liposomes containing DMHAPC-chol have been used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model. Liposomes containing DMHAPC-chol are cytotoxic to B16-F10 cells when used at lipid concentrations greater than 20 μM. DMHAPC-Chol, as part of a lipoplex with DOPE , has also been used to deliver DNA into mouse lung via intratracheal injection, resulting in a heterogeneous distribution in the bronchi and bronchioles, and to deliver VEGF siRNA into A431 and MDA-MB-231 cells, which secrete VEGF.

Bovine Protein C 经由 α-凝血酶或 α-凝血酶 血栓调节蛋白复合物激活，转化为丝氨酸蛋白酶，称为活化蛋白 C (APC)。其可以选择性地灭活因子 Va 和 VIIIa，是一种高效抗凝剂。

Drotrecogin alfa activated (DrotAA)为重组人活化蛋白C（APC）。该化合物能够抑制由烟雾引起的大鼠肺微血管通透性上升及促炎细胞因子IL-1β水平增加，具有抗凝血与抗炎作用，并促进纤溶过程。Drotrecogin alfa activated主要用于重症脓毒症的实验研究。

D-Lys(Z)-Pro-Arg-pNA is a luminescent substrate of activated protein C (APC).

The peptide region containing residues 390-404 in Activated Protein C (APC) is essential for anticoagulant activity and is available for interaction with antibodies or with other proteins, such as the macromolecular substrates Factors Va or VIIIa. APC reg

Activated Protein C (390-404), human, a peptide derived from the vitamin K-dependent serine protease, effectively suppresses the anticoagulant activity of APC[1].