Americanin A natural thrombin inhibitor, suppressing melanin synthesis, regulating the ATM ATR signaling pathway and the Skp2-p27 axis in human colon cancer cells.
Loline is a natural insecticidal and deterrent to a broad range of insects, including species in the Hemiptera, Coleoptera, Hymenoptera, Lepidoptera, and Blattodea orders. Loline deters species such as the bird cherry-oat aphid (genus Rhopalosiphum), larg
Advanced glycation end products (AGEs) are compounds formed by non-enzymatic chemical reactions following the bonding of sugars to proteins or lipids during diabetes, uremia, aging, rheumatic arthritis, and other conditions. A receptor for the AGEs (RAGE) binds certain members of this class to initiate cell signaling.[1][2] Pentosidine is a well-characterized natural AGE that is often used as a biomarker for the production of all AGEs. While pentosidine can be measured in urine, the majority of this AGE is catabolized before excretion.[3] Reference:[1]. Neeper, M., Schmidt, A.M., Brett, J., et al. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. The Journal of Biological Chemisty 267(21), 14998-15004 (1992).[2]. Brett, J., Schmidt, A.M., Yan, S.D., et al. Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues. American Journal of Pathology 143(6), 1699-1712 (1993).[3]. Miyata, T., Ueda, Y., Horie, K., et al. Renal catabolism of advanced glycation end products: The fate of pentosidine. Kidney International 53, 416-422 (1998).
D-Luciferin 6′-methyl ether (also known as 6′-Methoxyluciferin or compound 19a) is a highly effective inhibitor of luciferase obtained from the North American firefly Photinus pyralis (referred to as PpyLuc). It exhibits an IC50 value of 0.1 μM. This compound, which is an analog of D-luciferin, interacts non-specifically with the ATP and luciferin binding sites within the active site of PpyLuc.