Glasdegib Hydrochloride

Glasdegib hydrochloride is a small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity.

Glasdegib (PF-04449913) 是一种口服具有活力的 smoothened 抑制剂，能够结合到人 SMO(181-787氨基酸位点)，IC50=4 nM。