Duocarmycin DM free base

Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug–antibody conjugates (ADCs) . Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity.

Duocarmycin DM，一种DNA小沟烷基化剂（DNA minor-groove alkylator），作为抗体活性分子结合物（ADCs）的毒素，因其独特结构显示出抗癌活性。