Dequalinium Bromide

Dequalinium Bromide is a HIV-1 fusion inhibitor, targeting the membrane-proximal external region of Env spikes, specifically inhibiting the HIV-1 envelope-mediated membrane fusion by blocking CD4-induced conformational changes.

Dequalinium is a quaternary ammonium cation and bolaamphiphile commonly available as the dichloride salt. The bromide, iodide, acetate, and undecenoate salts are known as well.