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抑制剂&激动剂
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TargetMol产品目录中 "Compound W"的结果
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  • 抑制剂&激动剂
    12
    TargetMol | Inhibitors_Agonists
  • 天然产物
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    TargetMol | Natural_Products
  • 分子与细胞研究
    3
    TargetMol | Inhibitors_Agonists
  • 3,5-Bis(4-nitrophenoxy)benzoic acid
    3,5-二(4-硝基苯氧基)苯甲酸, Compound W
    T22678173550-33-9
    3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) 是 γ-secretase 抑制剂。它导致 Aβ42 和 notch-1 Aβ-like peptide 25 (Nβ25) 的释放水平降低。它是母体血清中 3,3’-diiodothyronine sulfate (T2S) 的交叉反应物质,可作为胎儿甲状腺功能减退的标志物。
    • ¥ 119
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • compound 10w
    T777711336890-05-1
    Compound 10w,一种取代吡唑并[1,5-a]嘧啶酰胺化合物,是一种ZSTK474 类似物,对 HeLa细胞显示出抗癌活性。
    • ¥ 475
    In stock
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  • AVX 13616
    T14359900814-48-4
    AVX 13616 shows the potent in vivo antibacterial activity of Avexa’s lead antibacterial candidate; particularly against drug-resistant Staphylococcus pathogens. IC50 value: 2-4 ug ml (MICs) Target: antibacterial agent AVX13616 was as active as mupirocin i
    • ¥ 10600
    待询
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    数量
  • (E)-Ajoene
    T3644892284-99-6
    (E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fungi (MICs = 15-50 μg/ml).1(E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 μM, respectively).2It also inhibits human glutathione reductase andT. cruzitrypanothione reductase when used at a concentration of 200 μM.3(E)-Ajoene (25 mg/kg) is neuroprotective in a gerbil model of ischemia-reperfusion injury, reducing reactive astrocytosis and microgliosis in the hippocampal CA1 region.4 1.Yoshida, H., Iwata, N., Katsuzaki, H., et al.Antimicrobial activity of a compound isolated from an oil-macerated garlic extractBiosci. Biotechnol. Biochem.62(5)1014-1017(1998) 2.Kaschula, C.H., Hunter, R., Hassan, H.T., et al.Anti-proliferation activity of synthetic ajoene analogues on cancer cell-linesAnticancer Agents Med. Chem.11(3)260-266(2011) 3.Gallwitz, H., Bonse, S., Martinez-Cruz, A., et al.Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: Crystallographic, kinetic, and spectroscopic studiesJ. Med. Chem.42(3)364-372(1999) 4.Yoo, D.Y., Kim, W., Nam, S.M., et al.Neuroprotective effects of Z-ajoene, an organosulfur compound derived from oil-macerated garlic, in the gerbil hippocampal CA1 region after transient forebrain ischemiaFood Chem. Toxicol.721-7(2014)
    • 待估
    35日内发货
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    数量
  • 3-hydroxy Myristic Acid methyl ester
    T3673755682-83-2
    3-hydroxy Myristic acid methyl ester is a hydroxylated fatty acid methyl ester that has been found in E. camaldulensis and E. torelliana extracts. [1] It is active against M. tuberculosis (MIC = 49.5 μg ml) and is non-cytotoxic to Vero cells (IC50 = >100 μM). 3-hydroxy Myristic acid methyl ester is also a volatile compound that contributes to the aroma of red wild strawberries (F. pentaphylla) but is not present in cultivated strawberries (Fragaria x ananassa).[2] Reference:[1]. Lawal, T.O., Adeniyi, B.A., Adegoke, A.O., et al. In vitro susceptibility of Mycobacterium tuberculosis to extracts of Eucalyptus camaldulensis and Eucalyptus torelliana and isolated compounds. Pharm. Biol. 50(1), 92-98 (2012).[2]. Duan, W., Sun, P., Chen, L., et al. Comparative analysis of fruit volatiles and related gene expression between the wild strawberry Fragaria pentaphylla and cultivated Fragaria × ananassa. Eur. Food Res. Technol. 244(1), 57-72 (2018).
    • 待估
    35日内发货
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    数量
  • Mcl-1 inhibitor 6
    T402302598978-56-2
    Mcl-1 inhibitor 6 is a potent, orally active chemical compound that selectively inhibits the myeloid cell leukemia 1 (Mcl-1) protein, with a high affinity (K d = 0.23 nM) and binding activity (K i = 0.02 μM). This compound exhibits exceptional selectivity over other members of the Bcl-2 family, including Bcl-2, Bcl2A1, Bcl-xL, and Bcl-w (K d >10 μM). Notably, Mcl-1 inhibitor 6 demonstrates strong antitumor activity.
    • ¥ 1290
    5日内发货
    规格
    数量
  • Calmodulin antagonist-1
    T4089578957-84-3
    Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist that effectively inhibits calmodulin-activated Ca 2+ -phosphodiesterase (PDE) with an IC 50 of 28 μM. This compound also competitively inhibits trypsin-treated Ca 2+ -PDE with respect to cyclic GMP, exhibiting an IC 50 of 375 μM and a K i value of 300 μM.
    5日内发货
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  • 1,2-Dilinoleoyl-3-Oleoyl-rac-glycerol
    TG(18:2 18:2 18:1), 1,2-Dilinolein-3-Olein
    T851062190-21-8
    1,2-Dilinoleoyl-3-oleoyl-rac-glycerol, a triacylglycerol, comprises linoleic acid at the sn-1 and sn-2 positions and oleic acid at the sn-3 position. This compound is present in the oils of ostrich and emu, and the fat body of male B. lapidarius bumblebees. It demonstrates efficacy in reducing scald development in Delicious apples, showing a 3% w v reduction when applied immediately after harvest and evaluated after six months of storage.
    • 待询
    8-10周
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  • 1,2-Dilinoleoyl-3-Palmitoyl-rac-glycerol
    TG(18:2 18:2 16:0), 1,2-Linolein-3-Palmitin
    T851102190-15-0
    1,2-Dilinoleoyl-3-palmitoyl-rac-glycerol is a triacylglycerol featuring linoleic acid at the sn-1 and sn-2 positions and palmitic acid at the sn-3 position. Present in various vegetable oils such as poppy seed, hazelnut, maize, and olive, this compound (3% w v) effectively reduces scald development in Delicious apples when applied right after harvest, with results observed after six months of storage.
    • 待询
    8-10周
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  • (-)BI97D6
    T894411430067-36-9
    (-)BI97D6 作为一种作用于广谱Bcl-2蛋白家族的抑制剂,其对Mcl-1、Bcl-2、Bcl-xL和Bcl-1的IC50值依次为0.025、0.031、0.076和0.122 μM.该化合物通过激活Bak和Bax介导的线粒体途径引发细胞的凋亡(apoptosis).特别是在抑制Mcl-1方面,(-)BI97D6能有效促使急性髓性白血病(AML)细胞走向凋亡(apoptosis).
    • 待询
    10-14周
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  • 1-Isothiocyanato-6-(methylsulfenyl)-hexane
    Lesquerellin
    TN75024430-39-1
    1-Isothiocyanato-6-(methylsulfenyl)-hexane, identified in wasabi (W. japonica), exhibits multifaceted biological activities. This isothiocyanate compound demonstrates antibacterial properties by inhibiting B. subtilis growth in an agar diffusion assay at 25 µmol disc, and antifungal effectiveness against T. mentagrophytes with a minimum inhibitory concentration (MIC) of 25 µg ml. Additionally, it acts as a repellent in the blue mussel (M. edulis) assay and shows antifouling capabilities on polyvinyl chloride (PVC) plates at a concentration of 50 µmol cm^2, underscoring its potential in biotechnological applications.
    • 待询
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  • Tetrapropylammonium hydroxide (40% w/w in water)
    TYD-018544499-86-9
    Tetrapropylammonium hydroxide (40% w w in water) 是一种季铵化合物,具有强碱性和阳离子特性。通常作为相转移催化剂,在有机合成中促进反应物在不混溶相间的转移。此外,它在半导体生产中应用广泛,尤其是在薄膜晶体管及其他电子设备的制造中。
    • 待询
    5日内发货
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