5hete

5(R)-HETE is a rare lipoxygenase product of arachidonic acid. Nearly all plant and animal 5-LOs produce 5(S)-HETE, but the presence of a 5(R)-LO and the synthesis of 5(R)-HpETE and 5(R)-HETE have been confirmed in oocytes of the bivalve mollusk, S. solidissima. 5(R)-HETE is more potent than the (S)-enantiomer as a chemotactic agent for human neutrophils.

5(S)-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of 5(S)-HETE. The ability of (±)5-HETE lactone to inhibit rat basophilic leukemia cell 5-lipoxygenase (IC50 = 27 μM) may be entirely due to the 5(S) isomer, but the enantiomers have not been tested separately.

Croconazole 对中性粒细胞的 5-脂氧合酶 (5-LOX) 表现出剂量依赖性抑制活性。Croconazole 是一种抗真菌剂。Croconazole 对合成白三烯 B4 (LTB4) 和 5-羟基二十碳四烯酸 (5-HETE) 的 IC50 分别为 7.8 ± 1.7 和 7.6 ± 0.3 μM。

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Astragalus polyphenols) 是分离自蓼属植物物种的根中，对5-HETE、HHT、thromboxane B2的形成具有抑制作用。

5-HETE是一种通过脂氧合酶活性产生的花生四烯酸氧化衍生物的脂肪酸代谢物，以 5(S)-HETE 和 5(R)-HETE 对映异构体的外消旋混合物形式存在。作为强效聚集诱导剂，它能以约 200 nM 的 IC50 值诱导人中性粒细胞聚集。

(±)15-HETE是一种二十烷酸类化合物，具有内在生物活性，并作为多种其他生物活性脂质衍生衍生物生物合成的关键酶促前体。此外，(±)15-HETE可作为蛋白水解靶向嵌合体（PROTAC）连接子，用于化学合成多种设计用于靶向蛋白降解的PROTAC分子。

(±)5-HETE, a monohydroxy fatty acid, emerges from the non-enzymatic oxidation of arachidonic acid and is one of six such derivatives. Its methyl ester variant exhibits no unique biological activity and serves as a provided standard. This methyl ester can also be present in oxidatively degraded polyunsaturated fatty acid (PUFA) methyl esters.

15-HETE-CoA (15-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-coenzyme A) 是一种不饱和的脂肪酰辅酶 A。