3 deoxy d glycero d galacto 2 nonulosonic acid

Sialic acids, commonly present as terminal carbohydrates on glycoconjugates, are essential for a variety of cellular functions including cell adhesion and signal recognition, as well as the formation and progression of tumors. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid is a deaminated sialic acid that was first identified at the nonreducing ends of oligosialyl chains in rainbow trout egg glycoprotein.[1] It is thought to be a precursor for the biosynthesis of other members of the sialic acid family.[2] 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid can be used to analyze nonulosonic acid residues in polysialoglycoproteins.[1]

3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) sodium 是一种唾液酸，能够保护寡/(聚)唾液酸链不受非还原端外切唾液酸酶的影响，并且在鲑科鱼类的卵激活过程中发挥作用。此外，3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid sodium 在胎儿脐带红细胞与人类恶性卵巢癌细胞中含量丰富。