β-amyloid , rat

β-Amyloid (1-38), derived from mice and rats, is a chemical compound comprising 38 amino acids, specifically residues 1-38 of the Aβ peptide. Notably, it serves as the primary constituent of amyloid plaques associated with Alzheimer's disease.

β-Amyloid (1-16) rat 是β-淀粉样肽 (Abeta) 金属结合域的片段，含有三个与人类相异的氨基酸替代，因此在大鼠和小鼠中降低了 AD 样神经退行性变的易感性。

β-Amyloid (1-42), rat mouse是一种由42个氨基酸组成的多肽，能够对海马切片产生明显的神经毒性作用，导致神经元损伤和功能障碍，常用于构建体外和体内的阿尔茨海默症模型。

β-Amyloid (1-42), rat TFA is a 42-aa peptide, shows the effects of cytotoxicity on acute hippocampal slices, and has been used in studies of alzheimer's disease.

Beta-Amyloid(1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide. This peptide is amino acids 1 to 14 fragment of Beta-Amyloid peptide.

Neuropeptide Y (29-64), amide, human acetate 参与阿尔茨海默病 (AD) 并保护大鼠皮质神经元免受 β-淀粉样蛋白毒性。

E 2012 是一种γ 分泌酶调节剂，不会影响 Notch 加工，在胆固醇生物合成的末步抑制 3β-羟基固醇 Δ24-还原酶。它能够减少淀粉样蛋白 β-42 减少阿兹海默氏病，并在大鼠多次重复给药后诱发白内障。

SKQ1，又名Visomitin或者plastoquinonyl decyltriphenyl phosphonium (PDTP)，是一种高效的针对线粒体的抗氧化剂。作为Visomitin滴眼药水的活性化合物成分（API），SKQ1展现了多种生物医学活性：(1) 防止淀粉样β蛋白导致的大鼠海马切片长时程增强功能受损；(2) 逆转大鼠的老化相关生物标志物；(3) 减缓Wistar和OXYS大鼠的视网膜及其血管层的老化相关破坏性变化；(4) 在LP或SPF环境下延长雄性啮齿类动物的寿命。SKQ1能够穿透细胞膜，被提议用于抗衰老治疗。Visomitin的API SKQ1目前在俄罗斯进行临床试验以治疗青光眼。注意：为了使用方便，SKQ1提供为乙醇-水（1:1, v v）溶液，浓度为200mg mL。

Dactylorhin B is an active compound isolated from Coeloglossum Viride. Dactylorhin B reduces the toxic effects of β -amyloid fragments (25-35) on neuron cells and isolated rat brain mitochondria, which play an important role in neurodegenerative diseases.

β-Amyloid (1-42), rat mouse TFA 是由42个氨基酸组成的多肽片段，对海马切片具有神经毒性，常用于构建阿尔茨海默症模型并开展相关研究。

16F16 is a protein disulfide isomerase (PDI) inhibitor.1It inhibits PDI reductase activity in an enzyme assay when used at concentrations ranging from 1 to 100 μg/ml.116F16 reduces PC12 cell apoptosis induced by the misfolded huntingtin protein HTTQ103. It suppresses PDI-dependent mitochondrial outer membrane permeabilization (MOMP) in isolated PC12 cell mitochondria. 16F16 (2, 3, 4, and 10 μM) reduces HTTN90Q73mutant huntingtin-induced medium spinal neuron death and MOMP in rat corticostriatal slices. It also reduces pyramidal neuron death induced by amyloid-β precursor protein (APP) in rat corticostriatal slices. 1.Hoffstrom, B.G., Kaplan, A., Letso, R., et al.Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteinsNat. Chem. Biol.6(12)900-906(2010)

Neuropeptide Y (human) TFA, a compound implicated in Alzheimer's disease (AD), exhibits protective effects against β-Amyloid toxicity in rat cortical neurons.

Biotin-amyloid-β (1-42) peptide is an affinity probe that allows amyloid-β (1-42) (Aβ42) to be detected or immobilized through interaction with the biotin ligand. It has been used to identify Aβ42 interaction partners in rat hippocampal synaptosomal membranes.

Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide. It forms fibrils that react to thioflavin T and Congo red and are organized in a cross-β arrangement of β-strands similar to Aβ (1-40) and Aβ (1-42) fibrils. Aggregated Aβ (25-35) decreases the viability of rat adrenal PC12 cells. It also decreases the viability of primary rat cortical neurons at concentrations ranging from 1 nM to 30 μM. In vivo, intracerebral injection of Aβ (25-35) (20 nmol) in rats induces lesions of neuronal and tissue loss. Aggregated Aβ (25-35) administered intracerebroventricularly to rats induces learning and memory impairments in the Y-maze, novel object recognition, and contextual fear conditioning tests.

[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) 是Y1受体的选择性激动剂。与阿尔茨海默病相关，该化合物能够保护老鼠皮质神经元免受淀粉样蛋白毒性的损害。

β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA是β-淀粉样蛋白22-35残基段，具细胞毒性，能影响无血清培养大鼠海马神经元。在中性缓冲液中，此化合物能形成聚集体与典型淀粉样纤维，模拟β-淀粉样蛋白行为。

Amylin (8-37), rat, is a truncated analog of native Amylin that selectively inhibits insulin-related glucose uptake and glycogen deposition in muscle tissue. Also known as islet amyloid precursor peptide (IAPP), Amylin is co-secreted with insulin.

Neuropeptide Y (29-64), amide, human (TFA) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.It is showed that Neuropeptide Y (29-64), amide, human (TFA) is able to protect cortical neurons from Aβ25-35 t

Rat form of the beta-Amyloid (1-40) peptide