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Neuropilin-2 Protein, Human, Recombinant (hFc)

Neuropilin-2 Protein, Human, Recombinant (hFc)

产品编号 TMPY-03763
别名: Neuropilin-2, NPN2, neuropilin 2, PRO2714, VEGF165R2, NP2

Neuropilin-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 120.7 kDa and the accession number is O60462-3.

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Neuropilin-2 Protein, Human, Recombinant (hFc)
规格 价格/CNY 货期 数量
50 μg ¥ 3,820 现货
100 μg ¥ 6,140 5日内发货
200 μg ¥ 9,850 5日内发货
500 μg ¥ 18,380 5日内发货
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产品目录号及名称: Neuropilin-2 Protein, Human, Recombinant (hFc) (TMPY-03763)
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生物活性
技术参数
产品性质
参考文献
生物活性 1.Measured by its binding ability in a functional ELISA. 2. Immobilized human VEGFC-His at 10μg/mL (100μL/well) can bind human NRP2-Fc , the EC50 of human NRP2-Fc is 0.1-1μg/mL.

TargetMol Bioactive

产品描述 Neuropilin-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 120.7 kDa and the accession number is O60462-3.
种属 Human
表达系统 HEK293 Cells
标签 C-hFc
蛋白编号 O60462-3
别名 Neuropilin-2, NPN2, neuropilin 2, PRO2714, VEGF165R2, NP2
蛋白构建 The Human NRP2 (NP_003863.2)(Met1-Tyr855) was expressed with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度 > 90 % as determined by SDS-PAGE

TargetMol

分子量 120.7 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation factor V/VIII homology domains, and a MAM (meprin, tyrosine phosphatase domain) region. NRP-2 is a receptor capable of binding two disparate ligands, classⅢ semaphorins (SEMA) and vascular endothelial growth factors (VEGF), and thus regulates two diverse systems by activating cellular signaling pathways via interacting with other cell surface receptors such as VEGF receptors and plexins. NRP-2 is well known for its role in facilitating axonal guidance during the development of the neuronal system, and additionally, it is also expressed in vascular endothelial cells and lymphatic endothelium where it affects proliferation, migration, angiogenesis, as well as the formation of small lymphatic vessels and capillaries. A recent study has identified NRP-2 as a polysialylation protein expressed in human dendritic cells and modulates DC-T Cell Interactions. Nearly all tumor cells express neuropilins and NRP-2 is predominantly expressed in neuronal tumors and melanomas. Furthermore, it is suggested that as the specific ligand for NRP-2, SEMA 3F inhibits tumor angiogenesis, and metastasis.

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Keywords

Neuropilin-2 Protein, Human, Recombinant (hFc) NP-2 Neuropilin-2 PRO 2714 NPN2 neuropilin 2 PRO-2714 NPN-2 PRO2714 NPN 2 VEGF165R2 NP2 NP 2 recombinant recombinant-proteins proteins protein

 

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