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M-CSF/CSF1 Protein, Human, Recombinant V2

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产品编号 TMPY-00127U

M-CSF/CSF1 Protein, Human, Recombinant V2 is expressed in HEK293 Cells. The accession number is P09603-1.

M-CSF/CSF1 Protein, Human, Recombinant V2

一键复制产品信息

产品编号 TMPY-00127U

M-CSF/CSF1 Protein, Human, Recombinant V2 is expressed in HEK293 Cells. The accession number is P09603-1.

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生物活性	Immobilized Human M-CSF at 0.5 μg/ml (100 μl/Well) on the plate. Dose response curve for Human M-CSF R, hFc Tag with the EC50 42.8 ng/ml determined by ELISA (QC Test). Human M-CSF, No Tag immobilized on CM5 Chip can bind Human M-CSF R, hFc Tag with an affinity constant of 2.06 nM as determined in SPR assay (Biacore T200). Measured in a cell proliferation assay using RAW264.7 cells.The ED50 for this effect is 2.5 - 7.0 ng/mL (QC Test).
产品描述	M-CSF/CSF1 Protein, Human, Recombinant V2 is expressed in HEK293 Cells. The accession number is P09603-1.
种属	Human
表达系统	HEK293 Cells
蛋白编号	P09603-1
别名	集落刺激因子,M-CSF,MCSF,CSF-1,colony stimulating factor 1 (macrophage)
蛋白构建	Glu33-Asn190
蛋白纯度	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
分子量	20.5 kDa (Predicted); 23-28 kDa (Due to glycosylation)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	CSF-1, also known as M-CSF , is a four alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. CSF-1 is also essential for the survival and proliferation of osteoclast progenitors.CSF-1 is cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand.