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CSF3R/G-CSFR Protein, Human, Recombinant (hFc)

产品编号 TMPY-00814

别名: G-CSF R, GCSFR, CD114, CSF3R, colony stimulating factor 3 receptor (granulocyte)

CSF3R/G-CSFR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 93.3 kDa and the accession number is Q99062-1.

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CSF3R/G-CSFR Protein, Human, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 2,270		5日内发货
1 mg	￥ 16,500		5日内发货

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生物活性

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参考文献

生物活性	Measured by its ability to inhibit GCSF-induced proliferation of NFS60 mouse myeloid cells. The ED50 for this ettect is typically 2-20 ng/ml in the presence of 0.125ng/ml of recombinant human GCSF.
产品描述	CSF3R/G-CSFR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 93.3 kDa and the accession number is Q99062-1.

种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	Q99062-1
别名	G-CSF R, GCSFR, CD114, CSF3R, colony stimulating factor 3 receptor (granulocyte)
蛋白构建	extracellular domain (Met 1-Pro 621) of Human G-CSF receptor (NP_000751.1) precursor
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	93.3 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regulator of granulopoiesis. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.

参考文献

1. Kasper B, et al. (1999) Association of src-kinase Lyn and non-src-kinase Syk with the granulocyte colony-stimulating factor receptor (G-CSFR) is not abrogated in neutrophils from severe congenital neutropenia patients with point mutations in the G-CSFR mRNA. Int J Hematol. 70(4): 241-7. 2. Hollenstein U, et al. (2000) Endotoxin down-modulates granulocyte colony-stimulating factor receptor (CD114) on human neutrophils. J Infect Dis. 182(1): 343-6. 3. Kindwall-Keller TL, et al. (2008) Role of the proteasome in modulating native G-CSFR expression. Cytokine. 43(2): 114-23. 4. Beel K, et al. (2009) G-CSF receptor (CSF3R) mutations in X-linked neutropenia evolving to acute myeloid leukemia or myelodysplasia. Haematologica. 94(10): 1449-52.

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Keywords

CSF3R/G-CSFR Protein, Human, Recombinant (hFc) CD 114 G-CSF R CD-114 GCSFR CD114 CSF3R GCSF colony stimulating factor 3 receptor colony stimulating factor 3 receptor (granulocyte) granulocyte recombinant recombinant-proteins proteins protein

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