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Anti-OLFM4 Polyclonal Antibody
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产品编号 TMAB-01284
别名 UNQ362, OLM4, OlfD, olfactomedin 4, hOLfD, hGC-1, GW112, GC1, bA209J19.1
Anti-OLFM4 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 OLFM4。Anti-OLFM4 Polyclonal Antibody 可用于 WB。
Anti-OLFM4 Polyclonal Antibody
Anti-OLFM4 Polyclonal Antibody
还可以产品编号 TMAB-01284 别名 UNQ362, OLM4, OlfD, olfactomedin 4, hOLfD, hGC-1, GW112, GC1, bA209J19.1
Anti-OLFM4 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 OLFM4。Anti-OLFM4 Polyclonal Antibody 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,165 | 5日内发货 | |
| 100 μL | ¥ 1,975 | 5日内发货 | |
| 200 μL | ¥ 2,795 | 5日内发货 |
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产品介绍
生物活性
抗原信息
化学信息
| 产品描述 | Anti-OLFM4 Polyclonal Antibody is a Rabbit antibody targeting OLFM4. Anti-OLFM4 Polyclonal Antibody can be used in WB. |
| 疾病造模方案 | |
| 别名 | UNQ362, OLM4, OlfD, olfactomedin 4, hOLfD, hGC-1, GW112, GC1, bA209J19.1 |
| Ig Type | IgG |
| 交叉反应 | Mouse (predicted:Human,Rat,Dog,Pig,Cow,Rabbit) |
| 验证活性 | Sample: Bone (Mouse) Lysate at 40 μg Primary: Anti-OLFM4 (TMAB-01284) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 55 kDa Observed band size: 55 kDa |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Secreted, extracellular space. Mitochondrion. Note=Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901 and PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901). |
| 组织特异性 | Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone mar |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1 mg/mL |
| 研究背景 | Olfactomedin-4, also known as G-CSF-stimulated clone 1 protein, Antiapoptotic protein GW112, and OLFM4, is a secreted protein which contains one olfactomedin-like domain. OLFM4 is expressed during myeloid lineage development. It is strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. OLFM4 is highly expressed in pancreatic cancer tissues and shows an elevated expression level during the early S phase of the cell cycle. It is also expressed at high levels in stomach cancer and colon cancer tissues. Inhibition of ROS or the ERK pathway remarkably decreased G-CSF-induced OLFM4 expression. OLFM4 is an antiapoptotic factor that promotes tumor growth. OLFM4 promotes proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. OLFM4 also facilitates cell adhesion. Induction of OLFM4 in cancer cells was reported to have a novel antiapoptotic action via binding to the potent apoptosis inducer GRIM-19. The human OLFM4 is also thought to be a useful marker for early myeloid development. |
| 免疫原 | KLH conjugated synthetic peptide: human OLFM4 |
| 抗原种属 | Human |
| 基因名称 | OLFM4 |
| 基因ID | |
| 蛋白名称 | Olfactomedin-4 |
| Uniprot ID | |
| 研究领域 | Tumor biomarkers |
| 功能 | May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. |
| 分子量 | Theoretical: 55 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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