Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Vinconate is an indolonaphthyridine derivative and can stimulate the muscarinic acetylcholine receptor.
产品描述 | Vinconate is an indolonaphthyridine derivative and can stimulate the muscarinic acetylcholine receptor. |
体内活性 | In dialysate dopamine concentrations significantly increased by Vinconate (50 to 200 mg/kg p.o.). Daily treatment with Vinconate (25 mg/kg) for 7 days also significantly increases dopamine and serotonin concentrations in dialysate[1]. In [3H]QNB binding in the nucleus accumbens and cerebellum, Chronic treatment with Vinconate at a 10 mg/kg significantly ameliorats the reduction . Furthermore, this Vinconate treatment significantly enhances [3H]QNB binding in the frontal cortex and hippocampus compare with the vehicle-treated aged animals. Also, chronic treatment with Vinconate at the higher dose significantly elevates [3H]QNB binding in the hippocampal CA3 sector and dentate gyrus compare with the vehicle-treated aged animals. Chronic treatment with Vinconate at a dose of 10 mg/kg shows a significant reduction in [3H]HC binding only in the hippocampal CA1 sector compare with the vehicle-treated aged rats[2]. |
别名 | Chanodesethylapovincamine |
分子量 | 296.36 |
分子式 | C18H20N2O2 |
CAS No. | 70704-03-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
( < 1 mg/mL refers to the product slightly soluble or insoluble )
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
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您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Vinconate 70704-03-9 Others Chanodesethylapovincamine Inhibitor inhibitor inhibit