Name: Streptolydigin
Brand: TargetMol
SKU: T16945
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

待询

3-6月

50 mg

待询

3-6月

100 mg

待询

3-6月

生物活性

产品描述	Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases. Streptolydigin is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor (Ki: 18 μM and a Kd: 15 μM).
靶点活性	RNA polymerase (bacterial):（ki）18 μM
体外活性	Streptolydigin inhibits initiation, elongation, and pyrophosphorolysis by bacterial RNA polymerase. Streptolydigin inhibits T. thermophilus RNA polymerase (a Ki: 1.8 μM). Binding of Streptolydigin to RNA polymerase strictly depends on a noncatalytic magnesium ion which is likely chelated by the aspartate of the bridge helix of the active center. Streptolydigin interacts with three structural elements within RNAP: the Stl pocket, the bridge helix, and the trigger-loop region. The Streptolydigin streptolol moiety interacts with the Streptolydigin pocket and bridge helix, and the Streptolydigin tetramic-acid moiety interacts with the trigger-loop region [1][3].
别名	Portamycin

化学信息

分子量	600.70
分子式	C₃₂H₄₄N₂O₉
CAS No.	7229-50-7
Smiles	C[C@@]12[C@]3(CO3)C=C[C@@H](O1)[C@H](C)[C@@]([C@@H](/C=C(/C=C/C(/O)=C/4\C(=O)N([C@@]([C@@H](C(NC)=O)C)(C4=O)[H])[C@]5(O[C@@H](C)[C@@H](O)CC5)[H])\C)C)(O2)[H]
密度	1.1852 g/cm3 (Estimated)