thrombin receptor agonist peptide

Thrombin receptor agonist peptide (TRAP-14) is a 14-amino acid peptide agonist of the α-thrombin receptor. It induces aggregation of washed platelets as well as platelets in citrated and hirudin plasma. TRAP-14 (100 μM) increases the cytosolic calcium concentration in isolated guinea pig pulmonary smooth muscle cells 5-fold over baseline. It increases pulmonary arterial pressure in isolated guinea pig lung when used at a concentration of 1 μM, which is comparable to the effect induced by 10 nM α-thrombin. TRAP-14 also induces contraction of isolated rat aortic rings and increases endothelin-1 (ET-1) levels in a dose-dependent manner, an effect that is reversed by the ETA antagonist BQ-123 and the nitric oxide synthase (NOS) inhibitor L-NNA .

Protease-Activated Receptor-1 (PAR-1) Agonist TFA is a selective peptide that acts as an agonist for the proteinase-activated receptor-1 (PAR-1). Corresponding to the tethered ligand of PAR-1, this compound mimics the actions of thrombin through the PAR-1 receptor[1][2].

Protease-Activated Receptor-1 (PAR-1) Agonist, a selective peptide, activates the PAR-1 receptor by mimicking the specific actions of thrombin. It corresponds to the PAR1 tethered ligand, facilitating selective activation of this receptor.

Protease-Activated Receptor-1, PAR-1 Agonist acetate 是一种选择性蛋白酶激活受体 1 (PAR-1) 激动剂肽。 它对应于 PAR1 栓系配体，可以选择性地模拟凝血酶通过该受体的作用。

TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide.

TRAP-6 amide acetate 是一种 PAR-1 凝血酶受体激动剂肽。

TRAP-6 amide TFA is a PAR-1 thrombin receptor agonist peptide.

Parstatin(mouse) TFA 是具有细胞通透性的 PAR-1凝血酶受体的肽类激动剂，是一种有效的血管生成抑制剂。

Parstatin(human) TFA 是具有细胞通透性的 PAR-1凝血酶受体的肽类激动剂，是一种有效的血管生成抑制剂。

TRAP-6 (Thrombin Receptor Activator Peptide 6) 是一种多肽片段，是选择性的蛋白酶激活受体 1 (PAR1) 激动剂，通过凝血酶受体激活人血小板。

TFLLRNPNDK-NH2 是具备生物活性的肽类化合物，作为凝血酶受体激活肽（PAR-1 激动剂肽）能够可逆地与 PAR-1 结合，模拟凝血酶对底物蛋白通过水解作用产生的“束缚配体”。同凝血酶的作用相似，此肽能够增加液体与蛋白质的渗透性。

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2是一类具有生物活性的肽，作为蛋白酶激活受体1 (PAR-1) 的选择性激动剂，其特异性优于PAR-2。该肽通过HEK293细胞进行的基于细胞的钙信号传导测定确认了其对PAR-1的高特异性，并可用于研究PAR-1在体内的激活。PAR-1除了介导凝血酶的多种细胞作用外，还与PAR-4协作，参与调控凝血酶诱导的被分类为“凝血型”的肝细胞癌。

PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)) 是一种蛋白酶激活受体 4 (PAR-4) 激动剂，对 PAR-1 或 PAR-2 均无影响，其作用可被 PAR-4 拮抗剂阻断。