tcep

TCEP-d16(hydrochloride) 是氘代的 TCEP hydrochloride。TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) 是一种稳定的非硫醇还原剂，具有比其他化学还原剂更快速的 S-S 键还原反应。作为一种三烷基膦，它能选择性地减少蛋白质的分解，而不改变其性质或与反应混合物中的硫醇导向剂发生相互作用。TCEP hydrochloride 也常用于 DNA/AuNP 化学中的还原反应。

TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) 是一种三烷基膦，可选择性地减少蛋白质的分解。TCEP hydrochloride 是一种非硫醇还原剂，可促进 NF-κB-DNA 的结合。

TCEP-biotin是生物素化的TCEP，可以用作蛋白质赖氨酸巴豆酰化的亲和探针。TCEP是一种硫醇类还原剂，可以定量地将简单有机二硫化物在水中裂解为巯基。

DBCO-S-S-PEG3-biotin 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。

PB1 is a highly-effective intracellular disulfide reducing agent with notable attributes such as excellent cell permeability, the capacity to generate a substantial intracellular concentration gradient, and remarkable stability. It serves as a borane-protected TCEP (tris(2-carboxyethyl)phosphine) analogue. PB1 demonstrates the potential to enhance the survival of retinal ganglion cells following axotomy in vitro at concentrations in the nanomolar and picomolar range. Consequently, PB1 has proven instrumental in the study of neuroprotective properties[1][2][3].

PB2, a tris(2-carboxyethyl)phosphine (TCEP) analogue, enhances the survival of retinal ganglion cells (RGCs) following axotomy in vitro. Even at nanomolar and picomolar concentrations, PB2 demonstrates pronounced efficacy in promoting RGC survival. Notably, PB2 exhibits superior permeability compared to TCEP. Serving as a potent reducing agent, PB2 provides robust neuroprotection for RGCs[1].

Biotin-PEG4-SS-acid 是一种可裂解试剂，能够有效将生物素部分结合到含胺生物分子上。该连接体中的二硫键可以通过还原剂（如 DTT、BME 和 TCEP）进行裂解，以去除生物素标记。