sth

STh, also known as Escherichia coli heat-stable toxin, is a 19 amino acid polypeptide containing three disulfide bridges. It serves as an antigen of significance in the quest for a comprehensive enterotoxigenic Escherichia coli (ETEC) vaccine.

Antiasthmatic Compound 1 is an antiasthmatic agent.

Asthma relating compound 1是一种潜在的抗哮喘化合物。

D-Desthiobiotin 是一种生物素衍生物，用于蛋白质层析和亲和层析，也用于蛋白质和细胞的标记、检测和分离。

Osthole (Osthol) 是一种天然抗组胺药替代试剂，可刺激成骨细胞增殖和分化。它可抑制组胺 H1受体活性，还可抑制细胞培养物中 HBV 的分泌。

Closthioamide is a potent inhibitor of bacterial DNA gyrase and highly active against MRSA, Ec, VRE, and Mv (MICs: 0.58 μM, 9.00 μM, 0.58 μM and 72.03 μM).

Pestheic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125639，CAS号为 165905-02-2。

Osthenone 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126372。

(5,6)TAMRA-PEG3-Azide-PEG3-Desthiobiotin is a polyethylene glycol (PEG)-based PROTAC linker utilized for the synthesis of PROTACs.

DBCO-PEG4-Desthiobiotin is a polyethylene glycol (PEG) derivative utilized as a linker for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

N-Desthiobiotin-N-bis(PEG4-NHS ester) is a polyethylene glycol (PEG) derived linker used for synthesizing PROTACs[1].

N-Desthiobiotin-N-bis(PEG4-t-butyl ester) is a PEG-based linker compound employed for the synthesis of PROTACs, which are bifunctional molecules designed for targeted protein degradation[1].

Desthiazolylmethyl ritonavir 是由HIV蛋白酶抑制剂Ritonavir在碱性条件下催化降解形成的产物。

Transthyretin-IN-3 (compound 6) 是一种设计精巧的苯并呋喃类似物。它能选择性地结合血浆中的转甲状腺素，抑制淀粉样蛋白的聚集（IC50=5.0±0.2 μM）。Transthyretin-IN-3 由于其结构中特定位置的氯取代基，可以有效结合到TTR的甲状腺素结合位点，从而阻止TTR四聚体解离为不稳定的单体。

Hydrazide-PEG4-Desthiobiotin 是一种 PROTAC linker，归类于 PEG 家族，用于合成 PROTAC 分子。

Transthyretin-IN-4 (Compound B26) 是一种双价抑制剂，用于抑制转甲状腺素蛋白 (TTR) 淀粉样变性，具有 bIC50 为 0.09 µM 和 pIC50 为 1.4 µM 的作用。Transthyretin-IN-4 可用于研究射血分数保留的心力衰竭 (HFpEF) 和致命性心律失常。

Azide-PEG3-Desthiobiotin 是一种 属于 PEG 类的PROTAC linker，可用于合成 PROTAC 分子。

Desthiobiotin-PEG4-propargyl is a PEG-coupled PROteolysis TArgeting Chimeric (PROTAC) linker, employed for PROTAC synthesis.

Amine-PEG3-Desthiobiotin is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Amine-PEG4-Desthiobiotin is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Transthyretin-IN-1 (Compound 1d) is a potent inhibitor of transthyretin (TTR) fibril formation, making it a valuable tool for investigating Alzheimer’s disease [1].

Bisthianostat, also known as CF367 or CF367;-C, is a novel Orally Efficacious Pan-HDAC Inhibitor. Bisthianostat selectively binds to and inhibits HDACs, which inhibits deacetylation of histone proteins and leads to the accumulation of highly acetylated histones. This may result in an induction of chromatin remodeling, the inhibition of tumor oncogene transcription, and the selective transcription of tumor suppressor genes. This prevents cell division, induces cell cycle arrest and apoptosis. This may inhibit the proliferation of susceptible tumor cells. HDACs, upregulated in many tumor cell types, are a family of enzymes that deacetylate histone proteins.

Arsthinol is an antiprotozoal agent which may have anti-cancer activity. It was found that arsthinol, a trivalent organoarsenic compound (dithiarsolane), has been active in vitro on leukemia cell lines and offers a better therapeutic index than arsenic trioxide, as estimated by the ratio LD50/IC50. Arsthinol induced growth inhibition of NB4 cells at lower concentration (IC50 (concentration inhibiting growth by 50%) = 0.78 +/- 0.08 micromol/l after 24 h) than As(2)O(3) (IC50 = 1.60 +/- 0.23 micromol/l after 24 h) or melarsoprol (IC50 = 1.44 +/- 0.08 micromol/l after 24 h). Arsthinol-cyclodextrin complex demonstrated to have was more effective than arsenic trioxide (As2O3) and melarsoprol on the U87 MG cell line. Importantly, in the in vivo study, significant antitumor activity against heterotopic xenografts was observed after i.p. administration.

Desthiobiotin-Iodoacetamide是一种功能化试剂，由desthiobiotin和iodoacetamide(IAM）连接而成，可作为探针用于研究半胱氨酸反应性，也可作为ADC Linker。