stabilized

CHAPS 是一种两性离子洗涤剂，是一种 Cholic acid 的衍生物，可溶解膜蛋白。它用于稳定各种蛋白质-DNA 复合物，并可以保留溶液中蛋白质的生化活性。

UNC0224 是 G9a 的特异性抑制剂，Ki 为 2.6 nM，IC50 为 15 nM。 UNC0224 还有效抑制 GLP，IC50 值为 20-58 nM。

Lipofundin S is an emulsion containing soybean oil, glycerol, and soy phosphatides.

Docosyl Acrylate (Docosyl Acrylate (stabilized with MEHQ)) 可用于合成水凝胶。

VinylLaurate(stabilizedwithMEHQ)是一种高纯度生化试剂，适合作为生物材料或有机合成中间体，广泛应用于生命科学领域的研究与实验。

3-O-Ethyl-L-ascorbic acid 是一种具有增白能力的化妆品酪氨酸酶 (tyrosinase) 抑制剂，是一种稳定的维生素 C 衍生物。它还具有抗氧化能力。

KY-02327 是 KY-02061的一种类似物，具有代谢稳定性。KY-02327是Dishevelled (Dvl)-CXXC5相互作用抑制剂。KY-02327激活Wnt β-catenin 途径，从而促进成骨细胞分化。

PIH is a ciliogenesis inhibitor by microtubule destabilization that acts by antagonizing Hh signaling by repressing cilia biogenesis and disassembly of alpha-tubulin in its stabilized form.

HIF-1 alpha (556-574) is a 19-mer fragment of hypoxia-inducible factor-1, a master regulator of the response to oxygen homeostasis. Hypoxia-induced gene expression is initiated when the HIF-1 subunit is stabilized in response to a lack of oxygen.

DRX-065 is a stabilized and deuterated R-enantiomer of pioglitazone. DRX-065 has pharmacological properties desirable for the treatment of NASH (mitochondrial function modulation, non-steroidal anti-inflammatory effects, and glucose lowering effects) with

Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.

Calciseptine 是从黑曼巴Dendroaspis p. polylepis分离得到的天然神经毒素。含有60个氨基酸和四个二硫键，特异性阻断L型钙通道（calcium channel）[1]。

VinylDecanoate (stabilized with MEHQ) 被用作医药中间体。

fStAx-35R TFA,作为一种疏水碳链固定肽,主要通过破坏 β-catenin-TCF 相互作用来抑制 Wnt β-catenin 信号通路,常被用于癌症研究领域.

Palifosfamide (tromethamine) 是一种具有潜在抗肿瘤活性的合成烷基化剂。作为异环磷酰胺 (ifosfamide) 稳定的活性代谢物，Palifosfamide (tromethamine) 通过GC 碱基对不可逆地烷基化和交联DNA，导致了DNA 复制的抑制，并导致细胞死亡。与异环磷酰胺相比，Palifosfamide (tromethamine)的毒性较小。

BmK-M1，一种含64个氨基酸通过四个二硫桥交联形成的蝎子毒素，作用于抑制Na+通道，属于心脏毒素和神经毒素类。

NK314 is a novel synthetic benzo[c]phenanthridine alkaloid that shows strong antitumor activity. It inhibited topoisomerase II activity and stabilized topoisomerase II-DNA cleavable complexes. The DNA breaks occurred within 1h after treatment with NK314 even without digestion of topoisomerase II by proteinase K, whereas etoposide required digestion of the enzyme protein in cleavable complex to detect DNA breaks. Pretreatment with topoisomerase II catalytic inhibitors, ICRF-193 and suramin, reduced both cleavable complex-mediated DNA breaks and proteinase K-independent DNA breaks, but protease inhibitors and nuclease inhibitors only decreased the latter.

Taurodeoxycholic acid (Taurodeoxychloic acid) 是脱氧胆酸的胆汁酸牛磺酸共轭物，是一种人体代谢物，可稳定线粒体膜，减少自由基形成。Taurodeoxycholic acid 通过阻断钙介导的凋亡通路以及 Caspase-12 激活来抑制凋亡 (apoptosis)。Taurodeoxycholic acid具有神经保护活性，可用于研究 3-硝基丙酸诱导或稳定遗传的亨廷顿舞蹈病 (HD) 。

Laudanidine is a nitrile-stabilized ammonium ylide.

DM4-SMe is a cytotoxic part of antibody-drug conjugates (ADCs) and a metabolite of antibody-maytansin conjugates (AMCs) and tubulin inhibitors, which can also be stabilized by disulfide bonds or thioether The bond binds to the antibody. The IC50 of DM4-SM

DG046 is a novel potent phosphinic pseudopeptide ERAP1 inhibitor, binding in the ERAP1 active site, being stabilized by an unusual extensive network of π-stacking interactions

Coibamide A 是一种 N-甲基稳定的细胞毒性缩酚肽，具有强大的抗增殖活性。Coibamide A 通过mTOR 独立机制诱导自噬体积累。Coibamide A 诱导细胞凋亡。Coibamide A 抑制VEGFA VEGFR2表达并抑制胶质母细胞瘤异种移植物中的肿瘤生长。

Polyphemusin I 是一种具有卓越抗菌活性的天然抗菌肽，能有效对抗革兰氏阴性菌和革兰氏阳性菌。该化合物由 18 个氨基酸组成，并通过两个二硫桥形成稳定的两亲性反向平行 β-发夹结构。

DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50 of 0.9 nM. DAP-81 is currently in ongoing preclinical evaluations.