sar 1

[Sar1, Ile8]-Angiotensin II acetate 可激活 NADPH 和 NADH 氧化酶，并刺激血管平滑肌细胞中超氧阴离子的形成。 [Sar1, Ile8]-Angiotensin II acetate 对血管平滑肌有多种作用，包括正常动脉的收缩和培养细胞或病变血管的肥大或增生。

[Sar1, Ile8]-Angiotensin II 3TFA ([Sar1, Ile8]-Angiotensin II 3TFA (37827-06-8(free base))) 是一种对血管平滑肌具有多种作用的肽。

[Sar1, Ile8]-Angiotensin II (TFA) is a peptide compound that exerts various effects on vascular smooth muscle. These effects include the contraction of normal arteries as well as the hypertrophy or hyperplasia of cultured cells or diseased vessels.

[Sar1, Ile8]-Angiotensin II 是一种在血管平滑肌细胞中有多种作用（如正常动脉的收缩，培养的细胞或病变血管的肥大或增生等）的多肽，。

[Sar1,Thr8]-Angiotensin II 作为一种高效的血管紧张素 II 拮抗剂,不影响心脏功能,对心脏病患者而言,其使用可能具有安全性.

(Sar1,Ile4,8)-Angiotensin II是一种对angiotensin II type 1 receptor (AT1R)具有功能选择性的激动剂，能增强胰岛素受体 (IR) 信号和糖原合成，同时还能促进Akt和GSK3α β的磷酸化，这一过程被胰岛素刺激所增强。

The substitution with Sar at position 1 of angiotensin II resulted in a partial agonistic activity.

Saralasin acetate(34273-10-4 free base) 是一种非选择性血管紧张素 II 拮抗剂。

SAR-114137 是一种组织蛋白酶鞘氨醇激酶抑制剂，可用于研究软动脉炎和周围神经性疼痛。

SAR131675 是一种选择性的VEGFR3抑制剂，其IC50=23 nM。

(Rac)-SAR131675 是一种有效的、选择性的VEGFR3抑制剂，其IC50=23 nM。

Caspase-6-IN-1 is a novel Allosteric Inhibitor of Caspase-6 Activation, blocking the interaction between C6 and mHTT1-586.

SAR107375 是一种有效的、具有口服活性的凝血酶和factor Xa的抑制剂，其Ki值分别为1 nM和8 nM。

SAR125884 hydrochlorid (1116743-46-4(free base)) 是一种有效的选择性 MET 激酶抑制剂，具有良好的临床前毒性特征 (IC50=4.2 nM)。

Nanatinostat, also known as Tractinostat, CHR-3996 and VRx-3996, is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor CHR-3996 inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. This agent may upregulate HSP70 and downregulate anti-apoptotic Bcl-2 proteins more substantially than some first-generation HDAC inhibitors. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins.

SAR114137是一种具备高效性和强大生物活性的化合物。在晶体活性药物成分的物理处理中，SAR114137展示了其变化的无定形(API)含量。特别是经过各种喷射磨削技术处理后，其无定形API含量将显著减少。此外，SAR114137在药物制剂中还保持了良好的化学稳定性。

SAR127303 is an effective covalent inhibitor of MAGL. SAR127303 behaves as a selective and competitive inhibitor of mouse and human MAGL.

SAR-104772 is a novel inhibitor of TAFIa (activated thrombin-activatable fibrinolysis inhibitor).

(S)-SAR131675 作为SAR131675的S-对映体,是一种高效的选择性VEGFR3抑制剂,同时兼具点击化学试剂的功能.

SAR156497 is an exquisitely selective Aurora A, B, and C inhibitor with in vitro and in vivo efficacy with IC50 = 0.5 nM (Aurora A); 1 nM (Aurora B incenp); 3 nM (Aurora C incenp) respectively SAR156497 combines high in vitro potency with satisfactory metabolic stability and limited CYP 3A4 and PDE3 inhibition. In vitro, SAR156497 displayed high antiproliferative activity on a large panel of tumor cell lines without correlation with any particular genetic signature or Aurora kinases expression. It induced significant modulation of Aurora A and Aurora B biomarkers (p-Aurora A and pHH3, respectively) and cell polyploidy, as expected from Aurora A B inhibitors.

SAR125844 是高度选择性可逆ATP 竞争性的MET 受体酪氨酸激酶抑制剂，其IC50值为4.2 nM。能抑制细胞中MET 的自磷酸化。

Lifitegrast (SAR 1118) 是一种整合素淋巴细胞功能相关抗原 1 拮抗剂， 抑制 Jurkat T 细胞附着于ICAM-1的IC50为 2.98 nM。

N-Hydroxypipecolic acid (NHP) 是植物代谢产物和系统性获得性抗性调节剂，可与免疫信号水杨酸协调建立系统性获得性抗性，诱导系统获得性耐药对细菌和卵菌感染。它在植物叶片中系统地积累，以应对病原菌的侵袭。

AC-262536 是非甾体雄激素受体选择性调节剂，具有有益的合成代谢作用。它可以强效激动雄激素受体，亲和力为1-10 nM。