qs-inhibitor-1

QS inhibitor 1 is a novel potent inhibitor of quorum sensing (QS) pathways.

Equisetin, an N-methylserine-derived acyl tetramic acid isolated from the terrestrial fungus Fusarium equiseti NRRL 5537, functions as a Quorum-sensing inhibitor (QSI) that specifically attenuates QS-regulated virulence phenotypes in P. aeruginosa, presenting a potent lead for treating P. aeruginosa infections without hindering bacterial growth. This tetramate-containing natural product possesses antibiotic and cytotoxic properties, effectively inhibiting the growth of Gram-positive bacteria and HIV-1 integrase activity, yet it does not impact Gram-negative bacteria.

QS11 是一种ARFGAP1抑制剂(EC50:1.5 µM)。QS 11 能抑制 ARFGAP 过表达的乳腺癌细胞迁移。QS 11 通过影响蛋白质运输来增强 Wnt β-catenin 信号。

YXL-13 is a highly effective inhibitor of Pseudomonas aeruginosa (PAO1), with an IC50 value of 3.686 μM. It effectively hinders the expression of virulence factors and inhibits biofilm formation in PAO1. Moreover, YXL-13 significantly diminishes both the pathogenicity and drug resistance of PAO1 by inhibiting the quorum sensing (QS) system. Thus, YXL-13 holds great potential for studying antibacterial properties [1].

Quorum sensing-IN-7 (compound HSL 4) 作为一种群体感应 (QS) 抑制剂,具有显著的效果.该化合物通过与 CviR 蛋白的结合口袋中的 Leu 72 和 Gln 95 相互作用,显示出其活性.此外,Quorum sensing-IN-7 作为抗菌剂,在 0.25-1 mg mL 的浓度范围内,能有效抑制 C. violaceum 中的高丝氨酸内酯 (HSLs) 以及生物膜的形成.