propranolol

Propranolol glycol 为普萘洛尔的一种代谢产物,显示出瞬时抗惊厥活性.

rac-7-hydroxy Propranolol (hydrochloride) is a ring-hydroxylated isomer and metabolite of propranolol that is an antagonist at β-adrenergic receptors (0.95 potency relative to propranolol). It also demonstrates potent vasodilator activity (0.20 potency relative to propranolol; pA2 = 7.58).

(±)-4-hydroxy Propranolol β-D-glucuronide is a metabolite of (±)-4-hydroxy propranolol , which is a metabolite of propranolol. The apparent half-life of (±)-4-hydroxy propranolol β-D-glucuronide is similar to propranolol and 4-hydroxy propranolol. Propranolol is a β-adrenergic antagonist, and the active enantiomer, (S)-(-)-propranolol , has log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively.

Rac-Propranolol-d7 是 2H 标记的 Rac-Propranolol。Propranolol 是一种高效性的 β-adrenergic receptor (βAR) 拮抗剂，抑制 β1AR 和 β2AR，可用于研究心血管疾病和代谢疾病。

Propranolol D7 hydrochloride is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective antagonist of β-adrenergic receptor (βAR).

5-hydroxy Propranolol is a metabolite of propranolol , a β-adrenergic receptor antagonist. Propranolol is primarily metabolized in the liver, with cytochrome P450 isoform 2D6 directing ring hydroxylation and the generation of 5-hydroxy propranolol and related metabolites.

(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) 是一种抗肾上腺素受体拮抗剂，是一种普萘洛尔的活性较低的对映体。Dexpropranolol 是一种非选择性的β-adrenergic receptor 拮抗剂，对 β1AR 和 β2AR 具有高亲和力。

(S)-(-)-Propranolol hydrochloride 是一种有效的肾上腺素能受体 (β-adrenergic receptor) 拮抗剂，具有抗高血压活性和潜在的抗癌活性，对β1，β2，和β3受体有抑制作用。(S)-(-)-Propranolol hydrochloride 可改善严重烧伤患者的预后，可用于研究酒精症。

4-Hydroxy propranolol-d7 HCl 是 4-Hydroxy propranolol HCl 的氘代化合物。4-Hydroxy propranolol HCl 的 CAS 号为 14133-90-5。4-羟基普萘洛尔盐酸盐是普萘洛尔的活性代谢产物，其效力与普萘洛尔相当。它抑制β1-和β2-肾上腺素能受体（pA2s:8.24和8.26）。

4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic receptors (pA2s: 8.24 and 8.26).

Norpropranolol hydrochloride 是 Propranolol 的活性代谢物。

4-Hydroxypropranolol D7 hydrochloride is deuterium-labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic receptors

Phosphatase-IN-1（compound II-8）是Propranolol的衍生物，充当磷脂酸磷酸酶（Pah）的抑制剂。Phosphatase-IN-1能够与 MoPah1结合，展现出19.8 μM的亲和常数。Phosphatase-IN-1能够抑制植物病原体的生长，并显示出抗真菌特性，同时对稻苗和麦穗表现出无毒性。

Bupranolol is a non-selective beta blocker without intrinsic sympathomimetic activity (ISA), but with strong membrane stabilizing activity. Its potency is similar to propranolol. Bupranolol is quickly and completely absorbed from the gut. Over 90% undergo first-pass metabolism. Bupranolol has a plasma half life of about two to four hours, with levels never reaching 1 µg l in therapeutic doses. The main metabolite is carboxybupranolol, 4-chloro-3-[3-(1,1-dimethylethylamino)-2-hydroxy-propyloxy]benzoic acid – that is, the methyl group at the benzene ring is oxidized to a carboxyl group –, of which 88% are eliminated renally within 24 hours.

Pranolium is a quaternary dimethyl derivative of Propranolol, a well-known powerful betareceptor-blocking agent.

Butocrolol是一种氨基醇衍生物，具有β-肾上腺受体阻滞、抗心律失常和局部麻醉特性。其交感神经阻滞和抗心律失常效果与propranolol相当，但局部麻醉效果较低。

Butocrolol是一种含有β-阻滞剂、抗心律失常以及局部麻醉特性的氨基醇类衍生物。该化合物具有类似于普萃洛尔的交感神经抑制和抗心律失常效果，但其局部麻醉效果较弱。