photoactivated

Optovin 是可逆的光活化 TRPA1配体，可实现光介导的神经元兴奋。它通过与氧化还原敏感的半胱氨酸残基产生结构依赖性光化学反应激活 TRPA1。

Methoxsalen (NCI-C55903) 是一种呋喃香豆素化合物，是P450抑制剂。它具有补充骨脂的作用，能够用于湿疹、牛皮癣、白癜风及一些暴露在阳光下的皮肤淋巴瘤的研究

Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity.1 Without photoactivation, it is a weak inhibitor of PAD2 (IC50 = >100 μM) and is less potent than BB-Cl-amidine in inhibiting citrulline production in vitro (kinact/KIs = 2,300, 600, 1,000, and 10,510 M-1min-1 for PAD1-4, respectively) and does not inhibit histone H3 citrullination in HEK293T cells overexpressing PAD2 when used at concentrations up to 100 μM. However, it can rapidly be photoactivated with UV-A radiation to the more active cis-isomer, which is an irreversible, competitive inhibitor of histone H3 citrullination with an IC50 value of 9.1 μM.References1. Mondal, S., Parelkar, S.S., Nagar, M., et al. Photochemical control of protein arginine deiminase (PAD) activity. ACS Chem. Biol. 13(4), 1057-1065 (2018). Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity.1 Without photoactivation, it is a weak inhibitor of PAD2 (IC50 = >100 μM) and is less potent than BB-Cl-amidine in inhibiting citrulline production in vitro (kinact/KIs = 2,300, 600, 1,000, and 10,510 M-1min-1 for PAD1-4, respectively) and does not inhibit histone H3 citrullination in HEK293T cells overexpressing PAD2 when used at concentrations up to 100 μM. However, it can rapidly be photoactivated with UV-A radiation to the more active cis-isomer, which is an irreversible, competitive inhibitor of histone H3 citrullination with an IC50 value of 9.1 μM. References1. Mondal, S., Parelkar, S.S., Nagar, M., et al. Photochemical control of protein arginine deiminase (PAD) activity. ACS Chem. Biol. 13(4), 1057-1065 (2018).

Methoxsalen (Standard) 是 Methoxsalen 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Methoxsalen (NCI-C55903) 是一种呋喃香豆素化合物，是P450抑制剂。它具有补充骨脂的作用，能够用于湿疹、牛皮癣、白癜风及一些暴露在阳光下的皮肤淋巴瘤的研究

4-Azide-TFP-amide-SS-propionic acid 包含芳基叠氮化物、可裂解的二硫键和羧酸。芳基叠氮化物可以通过紫外线（250 至 350 nm）光激活，与生物分子结合。氟有助于稳定自由基中间体。羧酸在活化剂存在下与胺反应可形成酰胺键。二硫键可以通过还原剂裂解。

4-Azide-TFP-amide-SS-Sulfo-NHS 是一种包含芳基叠氮化物、可裂解二硫键和NHS酯的化合物。芳基叠氮化物可以通过紫外线（250 至 350 nm）进行光激活，与生物分子发生结合反应。氟原子在其中起到稳定自由基中间体的作用。而NHS酯可以与胺反应形成稳定的键。二硫键则可以通过还原剂进行裂解。

4-Azide-TFP-amide-PEG4-acid 是一种包含芳基叠氮化物和羧酸的化合物，配有 PEG 间隔基，能够提升水溶性并减少连接过程中的空间阻碍。芳基叠氮化物可通过UV（250 至 350 nm）光激活，与生物分子结合。氟则在稳定自由基中间体中起作用。羧酸在活化剂存在下能与胺形成酰胺键。