opg

CGP 71683 (free base) is a potent and highly selective non-peptide antagonist of the NPY Y(5) receptor in the study of obesity.

Boldine (1,10-Dimethoxy-2,9-dihydroxyaporphine) 是一种阿扑吗啡异喹啉生物碱，从山苍子根中提取获得，具有抗氧化、抗炎和细胞保护的活性。它能够抑制破骨细胞生成，并利用下调 OPG RANKL RANK 信号途径，改善骨破坏。它可用于研究类风湿性关节炎。

DOPG sodium 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67069，CAS号为 67254-28-8。

POPG sodium salt是一种带有一个负电荷的磷脂，是生物膜的组成部分，可用于研究生物膜的功能。

18:1 Lysyl PG (Lysyl-DOPG) 是一种阳离子磷脂，包含赖氨酸基团和 DOPG。

15-keto-Prostaglandin E2为内源性代谢产物，通过与STAT3Cys259残基结合，抑制STAT3激活作用。该化合物能够结合并稳定EP2与EP4受体，进而抑制乳腺癌细胞生长与进展，并通过激活PPAR-γ促进真菌生长。

Δ17-6-keto Prostaglandin F1α (Δ17-6-keto PGF1α), a cyclooxygenase (COX) metabolite produced from eicosapentaenoic acid (EPA) in a variety of tissues including seminal vesicles, lungs, polymorphonuclear leukocytes, and ocular tissues, alongside other 3-series COX products from EPA such as PGF3α, PGE3, and thromboxane B3, is potentially linked to a lower occurrence of glaucoma in individuals consuming a marine-rich (EPA-rich) diet.

17-phenyl trinor-13,14-dihydro Prostaglandin A2 is a synthetic analog of prostaglandin with relatively unexplored biological activity. Similarly structured, particularly in its lower side chain, to the PGF2α analog latanoprost, which is an approved glaucoma treatment, this compound presents an interesting subject for further pharmaceutical research and potential therapeutic applications.

1a,1b-Dihomo Prostaglandin F2α (1a,1b-dihomo PGF2α), a hypothetical product of adrenic acid in the COX pathway, is predominantly synthesized in the renal medulla, reflecting the selective distribution of adrenic acid in this region.

1-Oleoyl-2-hydroxy-sn-glycero-3-PG (sodium salt), a lysophospholipid with oleic acid (18:1) at the sn-1 position, finds application in creating micelles, liposomes, and various artificial membranes, notably in lipid-based drug delivery systems.

1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol (POPG) 用于制备细菌膜模拟物。

Muramyl dipeptide (MDP) 是合成的免疫反应肽，由 N-乙酰壁酸与 L-Ala-D-isoGln 的短氨基酸链相连。它通过MAPK 途径上调 Runx2 基因表达，直接促进成骨细胞分化，通过降低 RANKL OPG 比值间接抑制破骨细胞分化。它是通过Runx2诱导骨形成的诱导因子，也是NLRP1激动剂。

E0924G 是一种具有口服活性的PPARδ激活剂，其EC50为2.82 μM。它能够上调骨保护素 (OPG) 的表达，EC50为0.29 μM。E0924G 能够减少RANKL诱导的破骨细胞分化，并抑制RAW264.7巨噬细胞中的F-肌动蛋白环形成。此外，E0924G 还可以调节卵巢切除 (OVX) 和年龄相关性骨质疏松症模型中的骨密度和骨质流失。

E09241 is a novel OPG RANKL upregulator, increasing OPG expression without affecting RANKL expression, promoting osteoblast differentiation while inhibiting osteoclast differentiation, regulating OPG expression through canonical Wnt β-catenin signaling.