ng-13

3,3',5-Triiodothyronine-(tyrosine ring-13C6) 是 3,3',5-Triiodothyronine 的 13C 的标记化合物。3,3',5-Triiodothyronine 的 CAS 号为 5817-39-0。

Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities. 10(S),17(S)-DiHDHA is a DHA metabolite, also referred to as protectin DX (PDX). It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA. It differs from protectin D1 with respect to the stereochemistry of the C-10 hydroxyl and the double bond configuration at the 13 and 15 positions. 10(S),17(S)-DiHDHA blocks neutrophil infiltration in murine peritonitis by 20-25% at a dose of 1 ng mouse. It also inhibits platelet activation by both impairing thromboxane (TX) synthesis and TX receptor activation.

Aloenin aglycone (compound 13) 作为一种NF-κB抑制剂，可从芦荟渗出液中提取。它在抑制TNFα引发的NF-κB转录活性方面表现显著（IC50: 18.7 μM）。当HepG2细胞经10 ng mL TNFα处理时，以10 μM Aloenin aglycone处理能有效下调诱导型一氧化氮合酶（iNOS）及细胞间粘附分子1（ICAM-1）的基因表达。

Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the parasiteT. brucei brucei(IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani,P. omnivorum,T. basicola,R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis,P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decreases phorbol 12-myristate 13-acetate (TPA)- and ionomycin-induced increased expression of COX-2 (IC50= 1 μM) and protein levels of IL-2 in Jurkat cells (IC50= 5.2 μM).1 1.Rether, J., Serwe, A., Anke, T., et al.Inhibition of inducible tumor necrosis factor-α expression by the fungal epipolythiodiketopiperazine gliovirinBiol. Chem.388(6)627-637(2007) 2.Howell, C.R., and Stipanovic, R.D.Gliovirin, a new antibiotic from Gliocladium virens, and its role in the biological control of Pythium ultimumCan. J. Microbiol.29(3)321-324(1983) 3.Iwatsuki, M., Otoguro, K., Ishiyama, A., et al.In vitro antitrypanosomal activity of 12 low-molecular-weight antibiotics and observations of structure/activity relationshipsJ. Antibiot. (Tokyo)63(10)619-622(2010)

CYP51-IN-13 (compound 1m)，一种Fluconazole的类似物，表现为有效的抗真菌剂。该化合物在抑制Microsporum gypseum和Candida albicans时，其MIC80分别为62.5 ng mL和250 ng mL。

Adrenomedullin (13-52) is a truncated form of adrenomedullin (1-52) . It induces nitric oxide-dependent relaxation of and inhibits release of angiotensin II and endothelin-1 from isolated rat aorta. In vivo, adrenomedullin (13-52) decreases mean arterial pressure (MAP) in spontaneously and renal hypertensive rats in a dose-dependent manner. Adrenomedullin (13-52) (10-3,000 ng per animal) reverses increases in lobar arterial pressure induced by U-46619 in a dose-dependent manner in cats but has no effect on basal lobar arterial pressure or systemic arterial pressure. It also potentiates inflammatory edema and neutrophil accumulation in rats.

(±)13-HODE is one of the two racemic monohydroxy fatty acids resulting from the non-enzymatic oxidation of linoleic acid. It is the principle hydroxylated fatty acid in human psoriatic skin scales, with a mean concentration of 17 ng/mg.[1]

Callosobruchusic acid is an insect pheromone and monoterpene that has been found as a component of the copulation release pheromone erectin in azuki bean weevils (C. chinensis).1It induces copulation release activity in male azuki bean weevils (EC50= 6.5 ng insect). 1.Mori, K., Ito, T., Tanaka, K., et al.Synthesis and biological activity of optically active forms of (E)-3, 7-dimethyl-2-octene-1, 8-dioic acid (callosobruchusic acid): A component of the copulation release pheromone (erectin) of the azuki bean weevilTetrahedron39(13)2303-2306(1983)