mycelial growth

Pyrimorph 是一种杀真菌剂，对 oomycetes 具有良好抑菌活性。

Boscalid 是一种广谱羧酰胺类杀菌剂，通过与线粒体复合物 II 琥珀酸脱氢酶的泛醌位点结合来抑制真菌呼吸。

1-Naphthaleneacetic acid potassium salt (1-NAA Potassium Salt) 是一种合成的植物生长素，能够促进植物生长，也是一种PLA2抑制剂，IC50=13.16 μM。

Fluazinam 是一种具有广谱抗真菌活性的吡啶胺类杀菌剂，对核盘菌群的菌丝生长有很强的抑制作用。

Xyloidone (NSC-106453) 具有抗真菌活性，在 0.4-33.3 mg L 的范围内完全抑制 B. cinerea、Colletotrichum acutatum Simmonds、Colletotrichum gloeosporioides Simmonds、M. grisea 和 Pythium ultimum Trow 的菌丝生长。

Antifungalagent 118 (compound C22) 有效抑制V. mali菌丝生长，其机制为诱导氧化损伤并破坏细胞膜的完整性。

Dibenzylideneacetone (DBA) 作为一种抗真菌剂，特别针对Botrytis cinerea具有抑制作用，其IC50值为13.10 μg mL。该化合物在抑制B. cinerea生长方面表现出色，MIC值达到32 μg mL，而其对菌丝生长和孢子萌发的EC50值则分别为16.29 μg mL和14.64 μg mL。通过阻断几丁质酶活性，Dibenzylideneacetone有效防治樱桃番茄中的灰葡萄孢感染。

Laccase-IN-5 (Compound 2b) 是一种漆酶 (Laccase) 抑制剂，其IC50值为0.82 μM。Laccase-IN-5 可以增强细胞膜的通透性，抑制菌丝生长，破坏细胞壁，并诱发氧化应激反应。它对多种植物病原真菌和卵菌展现出抗真菌活性，并可抑制B. dothidea，EC50为0.96 mg L。

7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respectively). 7-oxo Staurosporine induces cell cycle arrest in the G2/M phase in human leukemia K562 cells with a minimal effective dose (MED) of 30 ng/ml. It is cytotoxic to P388 mouse leukemia cells that are resistant and susceptible to doxorubicin . 7-oxo Staurosporine inhibits growth of the mycelial, but not yeast form of C. albicans, C. krusei, C. tropicalis, and C. lusitaniae (MICs = 3.1-25 μg/ml). It increases sphingomyelin synthesis in CHO-K1 cells when used at a concentration of 50 nM.

Fosetyl-aluminum(乙膦铝)是一种系统性杀菌剂，广泛用于防治多种作物上的霜霉病、疫病和其他由卵菌纲真菌引起的病害,通过抑制孢子萌发和菌丝生长，有效保护植物免受病原菌侵害。Fosetyl-Al适用于多种作物，包括水果、蔬菜、观赏植物和草坪。

IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties.1,2,3 It is cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng ml).1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg ml) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.2,3 It is active against T. spiralis in vitro and in vivo.1 |1. Minami, Y., Yoshida, K., Azuma, R., et al. Structure of a novel macrodiolide antibiotic IKD-8344. Tetrahedron Lett. 33(48), 7373-7376 (1992).|2. Hwang, E.I., Yun, B.S., Yeo, W.H., et al. Compound IKD-8344, a selective growth inhibitor against the mycelial form of Candida albicans, isolated from Streptomyces sp. A6792. J. Microbiol. Biotechnol. 15(4), 909-912 (2005).|3. Loutet, S.A., El-Halfawy, O.M., Jassem, A.N., et al. Identification of synergists that potentiate the action of polymyxin B against Burkholderia cenocepacia. Int. J. Antimicrob. Agents 46(4), 376-380 (2015).

Kakuol 是一种有抗真菌活性的天然产物。

Triclopyricarb (SYP-7017) is a strobilurin fungicide that can be used in crops disease control. Triclopyricarb inhibits mycelial growth with EC 50 values ranged from 0.006 μg mL to 0.047 μg mL.

Dimethomorph是一种杀菌剂和甾醇生物合成抑制剂，能抑制真菌细胞壁的形成，主要用于防治霜霉菌和疫霉菌。Dimethomorph还能抑制MDA-kb2细胞中的雄激素受体 (AR) 活性，IC20=0.263 µM。

BI-10 是一种抗真菌化合物。BI-10 与氟康唑联合用药能够抑制菌丝的生长，积累 ROS，减少线粒体膜电位 (MMP)，改变膜通透性。

Pyraziflumid is a fungicide. Pyraziflumid is a novel member of succinate dehydrogenase inhibitor fungicides (SDHI). The average EC50 value was 0.0561 (±0.0263)μg ml for mycelial growth. There was no cross-resistance between pyraziflumid and the widely used fungicides carbendazim, dimethachlon and the phenylpyrrole fungicide fludioxonil.

Antifungalagent 106 (Compound Z31) 作为一种苯甲酸衍生物,主要针对Monilinia fructicola,展现出潜在的杀菌效果.该化合物表现出的抗真菌活性显示,其EC50为11.8 mg L.Antifungalagent 106的作用机制主要通过破坏细胞膜的完整性来实施,这导致膜的通透性增加及细胞内电解质的释放,从而抑制菌丝的正常生长.此外,Antifungalagent 106 也被应用于针对石果褐腐病的研究中.