monophosphoryl lipid a

Monophosphoryl lipid A (MPLA), also known as Glucopyranosyl lipid A, is an agonist of toll-like receptor 4. Derived from the cell wall of nonpathogenic Salmonella, MPLA is a valuable compound for research on immunization and vaccine development.

Monophosphoryl lipid A (free acid) 是一种激活toll-like receptor 4的化合物，常用于免疫学和疫苗研究领域。

3D-Monophosphoryl Lipid A-5 (free acid) 作为一种有效的TLR激动剂，常用于疫苗中作为佐剂，用以提升疫苗的免疫原性。

Monophosphoryl Lipid A-12 free acid，作为一个toll-like receptor4激动剂，主要应用于免疫和疫苗研究领域。该化合物以Monophosphoryl Lipid A-12 (free acid)的形式活跃于相关生物医学研究中。

3D-Monophosphoryl Lipid A-5 (3D-MPLA-5) triethylamine 作为一种TLR激动剂，主要用作疫苗佐剂，其主要功能是提升疫苗的免疫原性。

3D-Monophosphoryl Lipid A-5 (3D-MPLA-5) 是一种TLR激动剂，用于作为疫苗佐剂，以提高疫苗的免疫原性。

Monophosphoryl Lipid A-12 (MPLA-12) 是一种在生化反应中使用的试剂。

3D-Monophosphoryl Lipid (14) (3D-Monophosphoryl Lipid (14)) triethylamine 作为一种TLR激动剂，主要在疫苗开发中作为佐剂使用，以提升疫苗的免疫原性。

3D-Monophosphoryl Lipid (12,16) (triethylamine) 作为一种TLR激动剂，常用于疫苗佐剂，用以提升疫苗的免疫原性。

3D-Monophosphoryl Lipid A (14) (ammonium) 作为一种TLR激动剂，被广泛应用于疫苗佐剂，其主要功能是提升疫苗的免疫原性。

3D-Monophosphoryl Lipid (12,16) (3D-MPL (12,16)) free acid 是一种作为疫苗佐剂的TLR激动剂，能够增强疫苗的免疫原性。

3D-Monophosphoryl Lipid (12,16) (3D-MPL (12,16)) 一种在生化反应中使用的试剂。

ADL 08-0011 is an active metabolite of the μ-opioid receptor antagonist alvimopan. It is produced from alvimopan via amide hydrolysis by gut microbiota. ADL 08-0011 is a μ-opioid receptor antagonist (Ki = 0.25 nM). It is selective for μ-opioid receptors over κ- and δ-opioid receptors (Kis = 15.8 and 31.6 nM, respectively). ADL 08-0011 inhibits endomorphin 1-induced inhibition of electrically induced contraction of isolated guinea pig ileum (pA2 = 9.4). In vivo, ADL 08-0011 (0.03-1 mg kg) reverses loperamide-induced delayed gastric emptying in a rat model of castor oil-induced diarrhea.

Monophosphoryl lipid A (MPLA) is a natural agonist for the toll-like receptor-4 (TLR4). It is useful as an adjuvant in immunization. MPLA is a safe prophylactic agent and has immunotherapeutic applications. It induces tumor necrosis factor and interleukin (IL)-1β, however not as efficient as lipopolysaccharide (LPS). MPLA improves immune response during bacterial sepsis infection.

3D-Monophosphoryl Lipid (14) (3D-MPL (14)) 是一种在生化反应中使用的试剂。