ml-130

Nodinitib-1 (CID-1088438) 是 NOD1抑制剂(IC50:0.56 μM)。

diABZI STING agonist-1 trihydrochloride 是选择性的干扰素基因刺激受体(STING)激动剂，在人和小鼠中都能发挥作用，其 EC50值分别为 130 和 186 nM。

Rifampicin (Rifamycin AMP) 是一种广谱抗生素。Rifampicin 对结核杆菌有较强抗菌作用，对革兰氏阳性或阴性细菌、病毒等也有疗效。

Antifungalagent 130 (Compound A7) 是一种口服活性的抗真菌剂。对滑念珠菌和新型隐球菌展示出抑菌活性 (MIC= 0.12 ng/mL)，并表现出优异的抗毒力作用。其通过破坏真菌细胞的铁稳态，诱导氧化应激损伤，从而实现抗真菌效果。它可以抑制真菌毒力因子（如生物膜、荚膜、尿素酶和黑色素）的形成，并具备研究耐药性真菌感染的潜力。

15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2 . 15(R)-PTA2 does not inhibit collagen-induced platelet aggregation (IC50s = 120-130 μM). It does not affect gastric tone in isolated rat gastric fundus when used at concentrations of 0.5 or 1.5 μg/ml and is less effective than PTA2 at inhibiting prostaglandin-induced contraction of isolated rat stomach muscle.

Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities. It is a plant growth regulator that induces malformations in plant structure. Malformin A inhibits replication of tobacco mosaic virus (TMV) in local lesion and leaf-disc assays (IC50s = 19.7 and 45.4 μg/ml, respectively). It is cytotoxic to NCI-H460, MIA PaCa-2, MCF-7, SF-268, and WI-38 cancer cells (IC50s = 70, 50, 100, 70, and 100 nM, respectively), inhibits proliferation of PC3 and LNCaP cells (IC50s = 130 and 90 nM, respectively), and induces apoptosis and necrosis in PC3 and LNCaP cells. Malformin A also increases the accumulation of reactive oxygen species, decreases the mitochondrial membrane potential, and induces autophagy in PC3 and LNCaP cells. It is toxic to mice when administered intraperitoneally (LD50 = 3.1 mg/kg) but not orally up to doses of 50 mg/kg.

Streptazolin is a fungal metabolite originally isolated from S. viridochromogenes. It increases NF-κB activity when used at concentrations ranging from 60 to 130 μg/ml, at least in part, via PI3K signaling. Streptazolin enhances TNF-α secretion induced by LPS and enhances IL-8 secretion when used alone or in combination with LPS in THP-1 Blue cells.

Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/ml in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50 value of 130 μM for recombinant IDO. It was isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.

Libivirumab (17.1.41) 是一种人源化抗HBV 单克隆抗体。Libivirumab 显示中和活性，对 HBsAg 和 HBeAg 的 IC50值分别为 35、130 ng/mL。

Cystothiazole A 具有抗真菌活性，可抑制白色念珠菌、酿酒酵母和烟曲霉菌，其最低抑制浓度（MIC）分别为 0.4 μg/mL、0.1 μg/mL 和 1.6 μg/mL；同时对人类肿瘤细胞如 HPT-116 和 K562 细胞也显示出抑制活性，MIC 分别为 130 ng/mL 和 110 ng/mL；它不具有抗菌作用。