hydrate

2,2,2-Trichloroethanol 是非经典的 K2P 通道 TREK-1和 TRAAK 的激动剂。

Regadenoson is an A2A adenosine receptor agonist, a coronary vasodilator commonly used in pharmacologic stress testing.

Meclofenamate sodium is a potent non-steroidal anti-inflammatory agent, which can specifically inhibit chemokine-induced human polymorphonuclear leukocyte function: chemotaxis, degranulation, and superoxide anion free radical production.

Cefadroxil is a first generation aminocephalosporin with good patient compliance, a long-acting therapeutic effect, high solubility and relatively broad spectrum of anti-bacterial activity. Cefadroxil is also a substrate of the intestinal peptide transporter PepT1, which is primarily responsible for the drug's uptake across the apical membrane of small intestine.

5'-GTP trisodium salt hydrate, an activator of the signal-transducing G proteins, serves as a precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.

A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist that inhibits receptor-mediated calcium flux.

Bavisant dihydrochloride hydrate (JNJ31001074AAC) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD. in vivo: Mean change

BIX-01338 hydrate is an inhibitor of histone lysine methyltransferase.

Geodin hydrate 是一种从微生物中分离到的简单芳香类天然产物。

Fanapanel hydrate is a highly selective antagonist of AMPA/kainate with little activity against NMDA(Ki of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively).

Zoniporide hydrochloride hydrate is a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor. Zoniporide hydrochloride hydrate inhibits human NHE-1 with IC50 of 14 nM.

Ivacaftor hydrate is an orally bioavailable CFTR potentiator. It also is used for cystic fibrosis treatment.

Ribociclib succinate hydrate is a highly specific CDK4/6 inhibitor (IC50s: 10 nM and 39 nM, respectively). It also is over 1,000-fold less potent against the cyclin B/CDK1 complex.

Napsagatran hydrate is a novel and specific inhibitor of thrombin.

Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (IC50: 0.02 μM against HSV1-2). Pritelivir mesylate hydrate is an inhibitor of the viral helicase-primase complex. Pritelivir mesylate hydrate shows antiviral activity in vit

Hydroxypyruvic acid lithium hydrate is an intermediate in the metabolism of serine, glycine, and threonine. It is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase.

Methylbenzethonium chloride hydrate 在化妆品和药品配方中作为防腐剂，有效预防微生物生长，此外，该化合物对细菌、病毒和真菌展示出广泛的抗微生物活性。

UNC0638 hydrate 作为一种化合物，主要通过选择性抑制G9a和GLP组蛋白甲基转移酶达到其生物活性，其半抑制浓度(IC50)分别为15 nM和19 nM。在体外实验中，此化合物有效抑制TNBC（三阴性乳腺癌）细胞的侵袭与迁移。同时，作为EHMT1/2的抑制剂，它能在人红细胞祖细胞的培养中诱导胎儿血红蛋白(HbF)的表达。此外，UNC0638 hydrate 对FMDV（口蹄疫病毒）和VSV（水疱性口炎病毒）均显示出抗病毒活性，展现了其在多种表观遗传和非表观遗传靶标上的高效力和选择性。

Ouabain 是一种心脏类固醇，能够结合 Na(+), K(+)-ATPase 并抑制其活性。该化合物能增强心肌的收缩力，稳定心率，并促进心脏、血管和神经细胞在体外和体内的生长。

bpV(bipy) hydrate 是一种能有效抑制磷酸肌醇 3-磷酸酶 (PTEN) 及蛋白酪氨酸磷酸酶PTP-β和PTP-1B的化合物，其IC50分别为18、60.3和164 nM。

ALK/ROS1-IN-4 (hydrate) (example 13) 是一种靶向 ALK 和 ROS1 激酶的双重抑制剂。

N6-Benzoyl-9-β-D-arabinofuranosyladeninehydrate 是化合物 N6-Benzoyl-9-β-D-arabinofuranosyladenine 的水合形式。作为腺嘌呤核苷类似物，N6-Benzoyl-9-β-D-arabinofuranosyladenine 可以用作平滑肌血管扩张剂，并且已被证明能够抑制癌症进展。常见的相关产品包括 Adenosine phosphate、Acadesine、Clofarabine、Fludarabine phosphate 和 Vidarabine。

(2R,4R)-APDC hydrate ((2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid hydrate) 是一种作用于群 II 型代谢型谷氨酸受体 (mGluR) 的激动剂。(2R,4R)-APDC hydrate 通过抑制谷氨酸的释放、增强由D1受体激活引起的运动反应或降低脑源性神经营养因子 (BDNF) 水平，从而影响细胞的增殖。该化合物常用于研究癫痫及其他神经系统疾病。

D-Histidine hydrochloride hydrate 是一种具有抗菌活性的抗生物膜生成试剂，能够靶向细菌群体感应系统 (如RhlI/RhlR通路)。它通过非共价结合细菌调控因子或铜离子复合物，选择性抑制细菌生物膜形成和运动性。该化合物可下调群体感应相关基因表达，减少毒力因子 (如藻酸盐、蛋白酶) 的合成，并干扰细菌膜稳定性，从而抑制生物膜形成、促进成熟生物膜解体并增强抗生素敏感性。此外，D-Histidine hydrochloride hydrate 还是盐诱导肽形成 (SIPF) 反应的高效催化剂，通过与铜离子 (Cu2+) 形成复合物，促进氨基酸缩合生成二肽 (如二丙氨酸、二赖氨酸)。