duocarmycins

Seco-Duocarmycin TM is an agent of DNA alkylator belonging to Duocarmycins family that inhibits DNA synthesis. It used as the cytotoxic component in antibody-drug conjugates (ADC).

Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes.

DBCO-PEG4-VC-PAB-DMEA-PNU-159682, a drug-linker conjugate for antibody-drug conjugates (ADC), comprises the ADC linker DBCO-PEG4-VC-PAB and the potent ADC cytotoxin DMEA-PNU-159682. The cytotoxin includes metabolites of nemorubicin (MMDX) from liver microsomes and the ADC cytotoxin PNU-159682[1].

Fmoc-Val-Cit-PAB-Duocarmycin TM is a drug-linker conjugate designed for antibody-drug conjugation (ADC), utilizing the antitumor antibiotic Duocarmycin TM. It is connected through the linker Fmoc-Val-Cit-PAB.

Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA is an antibody-drug conjugate linker that incorporates the antitumor antibiotic Duocarmycin SA, connected through the Mal-PEG4-VC-PAB-DMEA-Seco linker, for targeted cancer therapy.

MC-Val-Cit-PAB-duocarmycin is an antibody-drug conjugate (ADC) linker that combines duocarmycin, a potent DNA minor groove-binding alkylating agent, with an antitumor drug through the MC-Val-Cit-PAB linker, exhibiting significant antitumor activity.

Vc-seco-DUBA (Duocarmazine) 是一种用于抗体偶联药物 (ADC) 的药物-连接子复合物(Linker-Payload),由强效的 DNA 烷化剂载荷 DUBA (Duocarmycin 类似物) 通过 Vc-seco 连接子连接而成。该偶合体旨在通过抗体的靶向性将高毒性的 DNA 烷化试剂精准递送至肿瘤细胞内部。DUBA 能够通过与 DNA 小沟结合并对其进行烷基化，诱导 DNA 损伤并触发肿瘤细胞凋亡，从而表现出极强的抗肿瘤活性。

Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells when combined with proton radiation in vitro.

(S)-Seco-Duocarmycin SA 是一种 DNA 烷化剂，也是具有高效抗肿瘤活性的抗生素，可用于合成 ADC 化合物。

Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.

Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA 是一种抗体-药物偶联物 (ADC)，由人源性抗CCL2 (趋化因子配体 2) 的抗体 Carlumab 和连接子 MC-Vc-PAB-DMEA-PEG2 以及 DNA alkylator Duocarmycin SA 缀合而成。Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA 可用于癌症研究。

Duocarmycin SA intermediate-2 是合成抗生素Duocarmycin SA的一个中间体，具有诱导双链 DNA 序列选择性烷基化 (alkylation) 的能力，并与质子辐射协同作用，显示出抗癌的细胞毒性。