dolastatin 15

Dolastatin 15, a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the anti-tubulin agent Dolastatin 10. Dolastatin 15 can be used as an ADC cytotoxin and it induces cell cycle arrest and apoptosis in m

Cemadotin free base(LU103793 free base) 是一种新型的抗限定性肽 ，是一种新型的抗有丝分裂肽 ，是Dolastatin 15的类似物 。Dolastatin 15是一种天然存在的细胞毒肽，可阻断有丝分裂并抑制微管（管蛋白），Ki 为1μM。Cemadotin 用于研究抗癌。

Tasidotin hydrochloride, a peptide analog of the antimitotic depsipeptide dolastatin 15, is an inhibitor of microtubule assembly and microtubule dynamics.

Tasidotin (亦称ILX-651)是一种口服活性合成微管靶向衍生物，源自海洋depsipeptide dolastatin-15。

Cemadotin hydrochloride is the salt from of Cemadotin (free base), also known as, LU103793, a mitosis inhibitor potentially for the treatment of solid tumours. Cemadotin is also a synthetic derivative of Dolastatin 15, an antiproliferative compound which was isolated from the mollusk Dolabella auricularia. Like Dolastatin 15, LU103793 is highly cytotoxic in vitro (IC50 = 0.1 nM). LU103793 inhibits microtubule polymerization in a concentration-dependent manner (IC50 = 7 microM). Treatment with this compound also induced depolymerization of preassembled microtubules. Cell cycle analysis of tumor cell lines treated with LU103793 indicated a block in the G2-M phase.